Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4-induced liver damage in rats
| Autor: | Kadejo Olubukola Adetoro, Sallau Abdullahi Balarabe, Owolabi Olumuyiwa Adeyemi, James Dorcas Bolanle |
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| Rok vydání: | 2014 |
| Předmět: |
Liver damage
lcsh:Arctic medicine. Tropical medicine genetic structures lcsh:RC955-962 CCL4 Hepatocurative complex mixtures Biochemistry Genetics and Molecular Biology (miscellaneous) chemistry.chemical_compound Medicine Carbon tetrachloride lcsh:QH301-705.5 Stem bark Traditional medicine business.industry Vitex doniana lcsh:Biology (General) chemistry Creatinine visual_art visual_art.visual_art_medium Bark business Basic Researches |
| Zdroj: | Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 6, Pp 480-485 (2014) |
| ISSN: | 2221-1691 |
| Popis: | Objective: To evaluate the hepatocurative effects of aqueous root bark, stem bark and leaves of Vitex doniana in carbon tetrachloride (CCl4) induced liver damage and non induced liver damage albino rats. Methods: A total of 60 albino rats (36 induced liver damage and 24 non induced liver damage) were assigned into liver damage and non liver damage groups of 6 rats in a group. The animals in the CCl4 induced liver damage groups, were induced by intraperitoneal injection with a single dose of CCl4 (1 mL/kg body weight) as a 1:1(v/v) solution in olive oil and were fasted for 36 h before the subsequent treatment with aqueous root bark, stem bark and leaves extracts of Vitex doniana and vitamin E as standard drug (100 mg/kg body weight per day) for 21 d, while the animals in the non induced groups were only treated with the daily oral administration of these extracts at the same dose. The administration of CCl4 was done once a week for a period of 3 weeks. Results: There was significant (P |
| Databáze: | OpenAIRE |
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