Synthesis and identification of conformationally constrained selective MMP inhibitors

Autor:	Patrick B. Mullins, Huey-Sheng Shieh, John N. Freskos, Anna M. Stevens, Roderick A. Stegeman, Joseph J. McDonald, Mischke Brent
Rok vydání:	1999
Předmět:	Models Molecular MMP Inhibitors Molecular model Matrix metalloproteinase inhibitor Stereochemistry Clinical Biochemistry Pharmaceutical Science Matrix Metalloproteinase Inhibitors Crystallography X-Ray Biochemistry Chemical synthesis Inhibitory Concentration 50 Matrix Metalloproteinase 13 Drug Discovery Inhibitory concentration 50 Collagenases Enzyme Inhibitors Molecular Biology chemistry.chemical_classification biology Chemistry Organic Chemistry Metalloendopeptidases Matrix Metalloproteinase 8 Enzyme Models Chemical Enzyme inhibitor biology.protein Molecular Medicine Matrix Metalloproteinase 1
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 9:1757-1760
ISSN:	0960-894X
Popis:	We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b7fa215cd2b5051d3c32cec8ba0ce7 https://doi.org/10.1016/s0960-894x(99)00285-1 Zobrazit plný text záznamu Full Text from ScienceDirect