Quantitative characterization of differential ion suppression on liquid chromatography/atmospheric pressure ionization mass spectrometric bioanalytical methods
| Autor: | Michael J. Avery |
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| Rok vydání: | 2003 |
| Předmět: |
Ions
Analyte Bioanalysis Accuracy and precision Chromatography Atmospheric pressure Chemistry Organic Chemistry Analytical chemistry Ion suppression in liquid chromatography–mass spectrometry Atmospheric-pressure chemical ionization Reference Standards Sensitivity and Specificity Mass Spectrometry Analytical Chemistry Ion Atmospheric Pressure Direct electron ionization liquid chromatography–mass spectrometry interface Chromatography High Pressure Liquid Spectroscopy Chromatography Liquid |
| Zdroj: | Rapid Communications in Mass Spectrometry. 17:197-201 |
| ISSN: | 1097-0231 0951-4198 |
| DOI: | 10.1002/rcm.895 |
| Popis: | Ion suppression is a known phenomenon in atmospheric pressure ionization mass spectrometry. These suppression effects have been shown to adversely affect the accuracy and precision of quantitative bioanalytical methods. This paper presents a simple procedure for determining the impact of differential ion suppression on bioanalytical methods that utilize atmospheric pressure ionization mass spectrometric (APIMS) detection. This procedure was applied to the assessment of two potential internal standards, and to determine selectivity issues for another analyte which was to be measured in multiple species. |
| Databáze: | OpenAIRE |
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