The Potential Role of Lung Ultrasound B-Lines for Detection of Lung Radio-Induced Toxicity in Breast Cancer Patients after Radiation Therapy
| Autor: | Emilio A.L. Gianicolo, Maria Grazia Andreassi, Maurizio Portaluri, Maria Patrizia D'Errico, Eugenio Picano, Maria Pia Vasti, Maria Fonte Petruzzelli, Francesco Tramacere |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms 030204 cardiovascular system & hematology Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Subclinical infection Ultrasonography Lung business.industry Interstitial lung disease Reproducibility of Results Middle Aged medicine.disease Radiation therapy Radiation Pneumonitis medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Toxicity Biomarker (medicine) Feasibility Studies Female Radiotherapy Adjuvant Radiology Radiotherapy Conformal Cardiology and Cardiovascular Medicine business |
| Zdroj: | Echocardiography (Mount Kisco, N.Y.). 33(9) |
| ISSN: | 1540-8175 |
| Popis: | Breast cancer patients exposed to doses of radiation after radiotherapy could develop toxicity to lung. Lung ultrasound (LUS) is able to detect interstitial lung disease by the evaluation of B-lines. The aim of our study was to assess the number of B-lines to diagnose lung involvement after chest radiotherapy.We measured LUS B-lines in the treated and contralateral lung of 20 breast cancer patients, 1-3 months after the end of radiotherapy and 1 year after previous LUS. The sum of the B-lines number in the 72 sites on anterior and posterior chest yielded a global B-lines score.B-lines were more numerous in treated (median: 21; 1st-3rd quartiles: 11-31) versus untreated hemithorax (median: 3; 1st-3rd quartiles: 1-5) in both examination at T1-3 months (Kolmogorov-Smirnov test P0.001) and T1 year (median: 21; 1st-3rd quartiles: 12-28 vs. median: 4; 1st-3rd quartiles: 1-10; Kolmogorov-Smirnov test P0.01). Within the treated hemithorax, B-lines were more frequent in the anterior than in the posterior chest in both examination at T1-3 months (Kolmogorov-Smirnov test: P0.0001) and T1 year (Kolmogorov-Smirnov test: P0.01). Abnormal scores (B-lines5) were present in 17/20 treated versus 7/20 untreated hemithoraxes (85.0 vs. 35.0%, P0.01) in the first LUS and likewise in 16/17 treated versus 7/17 in untreated hemithorax (94.1% vs. 41.2%, P0.01) after 1-year follow-up.Among women receiving radiotherapy after breast cancer, B-lines are present predominantly in the irradiated lung. These data suggest that B-lines by LUS could provide, at a subclinical stage, a radiation-free biomarker of radiotherapy-induced lung damage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |