Evaluation of Kinetic Entropy of Breast Masses Initially Found on MRI using Whole-lesion Curve Distribution Data: Comparison with the Standard Kinetic Analysis
| Autor: | David V Schacht, Federico Pineda, Sanaz A. Jansen, Rajiv Ganesh, Gillian M. Newstead, Jian Yulei, Akiko Shimauchi, Hiroyuki Abe |
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| Rok vydání: | 2015 |
| Předmět: |
Entropy
Contrast Media Breast Neoplasms Kinetic energy Statistics Nonparametric Lesion Image Interpretation Computer-Assisted medicine Humans Breast MRI Entropy (information theory) Radiology Nuclear Medicine and imaging Retrospective Studies Neuroradiology medicine.diagnostic_test business.industry Ultrasound Magnetic resonance imaging General Medicine Middle Aged Magnetic Resonance Imaging Kinetics ROC Curve Mann–Whitney U test Female medicine.symptom Nuclear medicine business |
| Zdroj: | European Radiology. 25:2470-2478 |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | To quantify kinetic heterogeneity of breast masses that were initially detected with dynamic contrast-enhanced MRI, using whole-lesion kinetic distribution data obtained from computer-aided evaluation (CAE), and to compare that with standard kinetic curve analysis. Clinical MR images from 2006 to 2011 with breast masses initially detected with MRI were evaluated with CAE. The relative frequencies of six kinetic patterns (medium-persistent, medium-plateau, medium-washout, rapid-persistent, rapid-plateau, rapid-washout) within the entire lesion were used to calculate kinetic entropy (KE), a quantitative measure of enhancement pattern heterogeneity. Initial uptake (IU) and signal enhancement ratio (SER) were obtained from the most-suspicious kinetic curve. Mann-Whitney U test and ROC analysis were conducted for differentiation of malignant and benign masses. Forty benign and 37 malignant masses comprised the case set. IU and SER were not significantly different between malignant and benign masses, whereas KE was significantly greater for malignant than benign masses (p = 0.748, p = 0.083, and p |
| Databáze: | OpenAIRE |
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