Regulatory RNAs in photosynthetic cyanobacteria
| Autor: | Wolfgang R. Hess, Matthias Kopf |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
differential RNA-seq
Review Article Environment Regulatory Sequences Ribonucleic Acid Cyanobacteria Microbiology 03 medical and health sciences Bacterial Proteins Stress Physiological Botany 030304 developmental biology Regulation of gene expression 0303 health sciences photosynthesis biology 030306 microbiology Anabaena Synechocystis gene expression regulation Gene Expression Regulation Bacterial Biotic stress biology.organism_classification Synechococcus comparative transcriptome analysis Cell biology sRNAs RNA Bacterial Infectious Diseases Photosynthetic bacteria Prochlorococcus Transcriptome Energy source |
| Zdroj: | FEMS Microbiology Reviews |
| ISSN: | 1574-6976 |
| DOI: | 10.1093/femsre/fuv017 |
| Popis: | Regulatory RNAs play versatile roles in bacteria in the coordination of gene expression during various physiological processes, especially during stress adaptation. Photosynthetic bacteria use sunlight as their major energy source. Therefore, they are particularly vulnerable to the damaging effects of excess light or UV irradiation. In addition, like all bacteria, photosynthetic bacteria must adapt to limiting nutrient concentrations and abiotic and biotic stress factors. Transcriptome analyses have identified hundreds of potential regulatory small RNAs (sRNAs) in model cyanobacteria such as Synechocystis sp. PCC 6803 or Anabaena sp. PCC 7120, and in environmentally relevant genera such as Trichodesmium, Synechococcus and Prochlorococcus. Some sRNAs have been shown to actually contain μORFs and encode short proteins. Examples include the 40-amino-acid product of the sml0013 gene, which encodes the NdhP subunit of the NDH1 complex. In contrast, the functional characterization of the non-coding sRNA PsrR1 revealed that the 131 nt long sRNA controls photosynthetic functions by targeting multiple mRNAs, providing a paradigm for sRNA functions in photosynthetic bacteria. We suggest that actuatons comprise a new class of genetic elements in which an sRNA gene is inserted upstream of a coding region to modify or enable transcription of that region. Hundreds of potentially regulatory small RNAs (sRNAs) have been identified in model cyanobacteria and, despite recent significant progress, their functional characterization is substantial work and continues to provide surprising insights of general interest. |
| Databáze: | OpenAIRE |
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