Circadian desynchronization triggers premature cellular aging in a diurnal rodent
| Autor: | Sylviane Gourmelen, Edith Grosbellet, Mathilde Arrivé, Paul Pévet, Stéphanie Dumont, Sandrine Zahn, François Criscuolo, Etienne Challet |
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| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male circadian rhythm medicine.medical_specialty DNA damage medicine.medical_treatment Carbohydrate metabolism chronic jet lag Biochemistry Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine telomere shortening Internal medicine Genetics medicine Animals Insulin Circadian rhythm Molecular Biology Cellular Senescence 030304 developmental biology 0303 health sciences Glucose tolerance test diabetes biology medicine.diagnostic_test Glucose Tolerance Test medicine.disease Muridae shift work Endocrinology [SDE]Environmental Sciences Sirtuin biology.protein Corticosterone Cell aging 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | FASEB Journal FASEB Journal, Federation of American Society of Experimental Biology, 2015, 29 (12), pp.4794-4803. ⟨10.1096/fj.14-266817⟩ |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fj.14-266817 |
| Popis: | Chronic jet lag or shift work is deleterious to human metabolic health, in that such circadian desynchronization is associated with being overweight and the prevalence of altered glucose metabolism. Similar metabolic changes are observed with age, suggesting that chronic jet lag and accelerated cell aging are intimately related, but the association remains to be determined. We addressed whether jet lag induces metabolic and cell aging impairments in young grass rats (2-3 mo old), using control old grass rats (12-18 mo old) as an aging reference. Desynchronized young and control old subjects had impaired glucose tolerance (+60 and +280%) when compared with control young animals. Despite no significant variation in liver DNA damage, shorter telomeres were characterized, not only in old animal liver cells (-18%), but also at an intermediate level in desynchronized young rats (-9%). The same pattern was found for deacetylase sirtuin (SIRT)-1 (-57 and -29%), confirming that jet-lagged young rats have an intermediate aging profile. Our data indicate that an experimental circadian desynchronization in young animals is associated with a precocious aging profile based on 3 well-known markers, as well as a prediabetic phenotype. Such chronic jet lag-induced alterations observed in a diurnal species constitute proof of principle of the need to develop preventive treatments in jet-lagged persons and shift workers. |
| Databáze: | OpenAIRE |
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