Whole-body MR-DWIBS vs. [18F]-FDG-PET/CT in the study of malignant tumors: a retrospective study
| Autor: | A. Maggialetti, F. Iuele, Nicola Maggialetti, M. Lasciarrea, D. Pinto, Artor Niccoli-Asabella, Giuseppe Rubini, A. Notaristefano, D. Cafagna, G. Palmiotti |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Whole body imaging Multimodal Imaging Double-Blind Method Fluorodeoxyglucose F18 Neoplasms medicine Humans Radiology Nuclear Medicine and imaging Whole Body Imaging Neuroradiology Retrospective Studies medicine.diagnostic_test business.industry Ultrasound Interventional radiology Magnetic resonance imaging Retrospective cohort study General Medicine Middle Aged Diffusion Magnetic Resonance Imaging Positron emission tomography Positron-Emission Tomography Female Radiology Tomography Radiopharmaceuticals business Nuclear medicine Tomography X-Ray Computed |
| Zdroj: | La Radiologia medica. 117(2) |
| ISSN: | 1826-6983 |
| Popis: | Our aim was to assess the overall diagnostic accuracy of magnetic resonance diffusion-weighted whole-body imaging with background signal suppression (MR-DWIBS) compared with ([(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT), considered the reference standard of whole-body tumour imaging modalities, in a series of consecutive patients with malignant tumour.Thirty-eight patients diagnosed with a malignant tumour over a 4-month period were enrolled in this retrospective, observational study. PET/CT and MR-DWIBS images were reviewed in double-blind manner by a nuclear medicine physician and radiologists with 4 years experience. Lesion size, standard uptake value (SUV) and apparent diffusion coefficient (ADC) were measured and calculated for each lesion.The qualitative analysis of MR-DWIBS and [(18)F]-FDG-PET/CT showed that two patients were negative at both techniques. MR-DWIBS was positive in 36 patients, 34 of whom were positive and two negative at [(18)F]-FDG-PET/CT, respectively. Two hundred and fifty-five lesions were identified by MR-DWIBS and 184 by [(18)F]-FDG-PET/CT, which was a significative discordance. Correlation between SUV and ADC of lesions positive at both techniques was not statistically significant. The mean difference between lesion size in [(18)F]-FDG-PET/CT and MR-DWIBS was not statistically significant. No correlation was found between glucose metabolism and water motion.MR-DWIBS may be used to evaluate localisation of parenchymal neoplasms but is less efficacious in characterising lymph-node and skeletal lesions. [(18)F]-FDG-PET/CT remains the best whole-body technique to identify lymph-node and skeletal lesions, but its limitation is identifying tumours with low glucose metabolism as in mucinous neoplasms. MR-DWIBS evaluation must be integrated with morphological images to increase MR diagnostic accuracy. |
| Databáze: | OpenAIRE |
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