Additional file3: of Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas

Autor: Tsukita, Yoko, Fujino, Naoya, Eisaku Miyauchi, Saito, Ryoko, Fumiyoshi Fujishima, Itakura, Koji, Yorihiko Kyogoku, Okutomo, Koji, Yamada, Mitsuhiro, Tatsuma Okazaki, Sugiura, Hisatoshi, Inoue, Akira, Okada, Yoshinori, Ichinose, Masakazu
Rok vydání: 2019
DOI: 10.6084/m9.figshare.7705673
Popis: Figure S1. A dose-dependent decrease in phosphorylation of Axl in PC9 cells by the Axl kinase inhibitor. Figure S2. Knockdown of Axl decreases mRNA expression of PD-L1, PD-L2 and CXCR6 in vitro. Figure S3. Immunoblots indicating decreases in phosphorylation of ERK1/2 and AKT by the Axl kinase inhibitor. Figure S4. A selective MEK1/2 inhibitor or an AKT inhibitor reduces PD-L1 mRNA expression in vitro. Figure S5. Diverse downstream pathways driven by Axl receptor tyrosine kinase in non-small-cell lung cancer. (DOCX 2506 kb)
Databáze: OpenAIRE