Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
| Autor: | Patricia Rodrigo-Armenteros, Amaia Bilbao-González, Alejandra Collía-Fernández, Juan Carlos Garcia-Monco, Markel Erburu-Iriarte, Mar Carmona-Abellán, Marian Gomez-Beldarrain, Ivan Caballero-Romero, Iñigo Oyarzun-Irazu, Antonio Cabrera-Muras, Daniel Martínez-Condor |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics Critical Illness Myopathy Neurology Exacerbation Disease Encephalopathy 0302 clinical medicine Medicine 030212 general & internal medicine Stroke Referral and Consultation Aged 80 and over Incidence (epidemiology) Incidence General Medicine Middle Aged Hospitalization Psychiatry and Mental health C-Reactive Protein Encephalitis Female Neurosurgery Coronavirus Infections Adult medicine.medical_specialty Neurological consultation Pneumonia Viral Clinical Neurology Dermatology Fibrin Fibrinogen Degradation Products 03 medical and health sciences Betacoronavirus Young Adult Seizures Humans Pandemics Aged Pandemic business.industry SARS-CoV-2 COVID-19 medicine.disease Cross-Sectional Studies Ferritins Neurology (clinical) Nervous System Diseases business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Neurological Sciences |
| ISSN: | 1590-3478 |
| Popis: | Background COVID-19 disease affects the nervous system and led to an increase in neurological consults for patients at admission and through the period of hospitalization during the peak of the pandemic. Methods Patients with clinical and laboratory diagnosis of COVID-19 that required a neurologic consultation or those who presented with neurological problems on admission that led to a diagnosis of SARS-CoV-2 infection during a 2-month period at the peak of the pandemic were included in this study. Demographic and clinical variables were analyzed. Results Thirty-five patients were included. The presenting neurologic manifestations on admission led to the diagnosis of COVID-19 in 14 patients (40%). The most common reasons for consultation during the hospitalization period were stroke (11), encephalopathy (7), seizures (6), and neuropathies (5) followed by a miscellaneous of syncope (2), migraine (1), anosmia (1), critical illness myopathy (1), and exacerbation of residual dysarthria (1). The most common neurological disturbances were associated with severe disease except for neuropathies. Patients with encephalopathies and seizures had markedly increased D-dimer and ferritin values, even higher than stroke patients. RT-PCR was performed in 8 CSF samples and was negative in all of them. Conclusion Neurological disturbances represent a significant and severe burden in COVID-19 patients, and they can be the presenting condition that leads to the diagnosis of the viral infection in a high percentage of patients. Evidence of direct viral mechanisms was scarce, but the pathogenesis of the diverse manifestations remains enigmatic. |
| Databáze: | OpenAIRE |
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