| Autor: |
Amin Mabrouk, Nadine El-Husseiny, Shahd Ragab, Kirollos Badr, Omar Medhat, Mostafa AmanAllah, Febronia Nasry, Basant Eltaher, Rawan Elsayed, Marihan Ghazy, Amr Elkhateb, Ramy Gayed, Shenoda Yacoub, Merna Luis, Aia Mohamed Hanoura, Yara Mahjoub, Mai Mustafa, Areeg ElShaarawy, Ahmed Sabry, Esraa Menshawey, Nadine Elgamal, Nourhan Hassan, Rania Abdelaziz, Elaria Yacoub, Assem Kassim, Yousef Husseiny, Mariam Abdelaziz, Noha M. Khalil, Omnia Mohamed, Nada Gamal, Mark Michael, Noha Abdelmoneim, Doaa Massoud, Rokaya El-Sayed, Passant Elshawarbi, Taquwa Aly, Rahma Hassan Galal, Youssef Nada, Estfana Eskandar, Emmy Abdelfatah, Aya Kamel, Lauren Nathan, Sara Tayssir, Rahma Menshawey, Joseph Shehata, Hutaf Jaber, Nada AlShehry, Antoine Fakhry AbdelMassih, Sherry Rateb, Reem J. Husseiny, Mahmoud Seyam, Omnya Mahmoud Aly, Hesham Sheashaa, Maram Rajab, Verina Fouad, Fady Mishriky, Peter Kelada, Alaa Saud, Reem Yasser, Marian Eesa, Mariam Messiha, Mayada Elfishawy, Nada Ali, Alaa Amr, Rana AbdelHaleem, Mariem Arsanyous, Rafeef Hozaien, Ahmed El-Maghraby |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-108776/v3 |
| Popis: |
Background:As more than 37 million confirmed cases and 1 million deaths worldwide from COVID-19, we flied to think about supporting immunity, So, there are more than 150 coronavirus vaccines and clinical trials are being developed. The success of those vaccines depends mainly on immunologic memory. People who are at high risk of re-infection with COVID-19 don’t show any evidence of having B-cell memory. 10-20% of infected patients don’t develop antibody response. randomized controlled trials and cross-sectional studies proved variant results about the effect of chronic exercise on vaccination function.The aim of this review is to suggest that exercise is an important adjuvant strategy for prevention of re-infection and for development of better protective responses following vaccination.Methods:Embase, Medline and the Cochrane Central Register were used to search for specific keywords such as “COVID-19” OR “SARS-CoV-2” AND “Re-infection” for relevant publications up to 1st of Nov. 2020. The systematic review was performed using PRISMA protocol.Results:According to inclusion criteria, 6 case reports from search and one case from a press conference were identified. The average age of re-infected patients was 36 years. The average intervening period between initial infection and reinfection was 105 days. 75% of cases who have been tested for antibodies after 1st infection were negative, and turned seropositive after second infection. 57% of cases developing re-infection had worse clinical manifestation.Conclusion:Regular moderate intensity exercise not only can enhance the secondary antibody response of B cell memory but also decrease the severity of re-infection and the adverse reactogenicity of potential vaccines under development. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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