New aggressive variant of suppressor/cytotoxic T-CLL
| Autor: | Alfred C. Feller, Stefano Pileri, Marco Gobbi, Karl Lennert, Pak K. Hui |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cytoplasm Adolescent CD3 Biology T-Lymphocytes Regulatory Azurophilic granule Antigen medicine Cytotoxic T cell Humans Histocytochemistry Acid phosphatase General Medicine medicine.disease Leukemia Lymphoid Leukemia Antigens Surface biology.protein Cytochemistry Cancer research Female CD8 Spleen T-Lymphocytes Cytotoxic |
| Zdroj: | American journal of clinical pathology. 87(1) |
| ISSN: | 0002-9173 |
| Popis: | Three cases of CD8+ CLL are reported. The patients are young (28, 18, 27 years old). The leukemia cells are predominantly small lymphocytes with irregular nuclei bearing notches and lobations. Cytoplasmic azurophilic granules are absent. Cytochemistry shows periodic acid-Schiff granular, alpha-naphthylacetate esterase focal, and acid phosphatase focal/granular positivities. Immunophenotypically cells are CD2+, CD3+, and CD8+ and lack CD4 as well as B-cell and NK cell antigens. All patients died within 20, 16, and 9 months, respectively. The clinicopathologic features of these cases differ clearly from those of the CD8+ CLL with azurophilic granules. These three cases represent a morphologically distinctive and more aggressive variant of CD8+ CLL. |
| Databáze: | OpenAIRE |
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