| Autor: |
Krystallenia Paniskaki, Moritz Anft, Constantin J. Thieme, Sarah Skrzypczyk, Margarethe Justine Konik, Sebastian Dolff, Timm H. Westhoff, Mikalai Nienen, Anna Stittrich, Ulrik Stervbo, Oliver Witzke, Guido Heine, Toralf Roch, Nina Babel |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Transplantation proceedings. 54(6) |
| ISSN: |
1873-2623 |
| Popis: |
Background: Immune responses to seasonal endemic coronaviruses might have a pivotal role in protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Those SARS-CoV-2-crossreactive T cells were recently described in immunocompetent individuals. Still, data on cross-reactive humoral and cellular immunity in kidney transplant recipients is currently lacking. Methods: The pre-existing, cross-reactive antibody B and T cell immune responses against SARS-CoV-2 in unexposed adults with kidney transplantation (Tx, n = 14) and without (non-Tx, n = 12) sampled before the pandemic were compared with 22 convalescent patients with COVID-19 (Cp) applying enzyme-linked immunosorbent assay and flow cytometry. Results: In both unexposed groups, SARS-CoV-2 IgG antibodies were not detectable. Memory B cells binding spike (S) protein SARS-CoV-2 were detected in unexposed individuals (64% among Tx; 50% among non-Tx) and higher frequencies after infection (80% Cp). The numbers of SARS-CoV-2-reactive T cells were comparable between patients who had undergone Tx and those who had not. SARS-CoV-2-reactive follicular T helper cells were present in 61% of the unexposed cohort in both patients who had undergone Tx and those who had not. Conclusions: Cross-reactive memory B and T cells against SARS-CoV-2 exist also in transplanted adults, suggesting a primed adaptive immunity. The effect on the disease course may depend on the concomitant immunosuppressive drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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