Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation
| Autor: | Zigang Li, Rui Wang, Shuiming Li, Feng Yin, Dongyuan Wang, Yang Li, Chuan Wan, Rongtong Zhao, Wanjin Zhong, Chenshan Lian, Wang Yuena, Zhanfeng Hou |
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| Rok vydání: | 2020 |
| Předmět: |
Alkylation
Sulfonium Stereochemistry Sulfonium Compounds Peptides Cyclic Catalysis chemistry.chemical_compound Methionine Materials Chemistry Humans chemistry.chemical_classification Metals and Alloys Intramolecular cyclization Biological Transport General Chemistry Cyclic peptide Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Cyclization Intramolecular force Ceramics and Composites HeLa Cells Cysteine Conjugate |
| Zdroj: | Chemical Communications. 56:3741-3744 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d0cc00377h |
| Popis: | Continuous efforts have been invested in the selective modification of proteins. Herein, we first report the construction of sulfonium tethered cyclic peptides via an intramolecular cyclization by an aliphatic halide. This cyclization could enhance the stability and cellular uptake of peptides. Furthermore, the sulfonium center could be recognized by cysteine in the vicinity of the protein-peptide interacting interface and form a peptide-protein conjugate. |
| Databáze: | OpenAIRE |
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