Presence of albuminuria predicts left ventricular mass in patients with chronic systemic arterial hypertension

Autor:	Esther, de Beus, Matthijs F L, Meijs, Michiel L, Bots, Frank L J, Visseren, Peter J, Blankestijn, F L J, Visseren
Rok vydání:	2015
Předmět:	Adult Male medicine.medical_specialty Adolescent Clinical Biochemistry Observational Study Renal function Disease Research Support Biochemistry Left ventricular mass Young Adult Risk Factors Chronic kidney disease Internal medicine Journal Article medicine Humans Albuminuria In patient Prospective Studies Non-U.S. Gov't Cardiac MRI Aged Medicine(all) business.industry Research Support Non-U.S. Gov't General Medicine Middle Aged medicine.disease Surgery Blood pressure Chronic Disease Hypertension Cardiology Regression Analysis Female Hypertrophy Left Ventricular medicine.symptom business Magnetic Resonance Angiography Glomerular Filtration Rate Kidney disease Cohort study
Zdroj:	European Journal of Clinical Investigation, 45(6), 550. Wiley-Blackwell
ISSN:	0014-2972
Popis:	Background Increased left ventricular mass (LVM) is known to predict cardiovascular morbidity and mortality. LVM is high in patients with advanced kidney disease. Our aim was to study the relationship between renal parameters and LVM in hypertensive subjects at high risk of cardiovascular disease. Design Cardiac MRI was performed in 527 patients participating in the single-centre SMART cohort study. Participants free from previous symptomatic coronary heart disease but with a history of hypertension were recruited. Subjects were screened for cardiovascular risk factors in a standardized way. Multivariable linear regression was used to study the relationship of both estimated glomerular filtration rate (eGFR) and presence of albuminuria with left ventricular mass. Results Mean LVM was 121 g for men (SD 26) and 87 g for women (SD 20). Mean eGFR was 82 mL/min/1·73 m² (SD 19). A total of 73 patients (14%) had albuminuria. After adjusting for known determinants of LVM (height, weight, sex and age) eGFR did not relate to LVM while presence of albuminuria did (mean change in LVM per 10 mL/min/1·73 m2 change in eGFR 0·79 g, 95% CI −0·33 to 1·91, P = 0·17, mean change in LVM in presence vs. absence of albuminuria 9·9 g, 95% CI 4·33 to 15·45, P = 0·001). Additional adjustment for systolic blood pressure did not change results (B for eGFR 0·54, 95% CI −0·58 to 1·66, P = 0·35, B for albuminuria 9·09, 95% CI 3·57 to 14·60, P = 0·001). Conclusions In this study in hypertensive patients with high vascular risk, albuminuria was related to increased LVM and eGFR was not.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cfd70cd75a2e34c2b7c406f339e134 https://doi.org/10.1111/eci.12433 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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