p202 Prevents Apoptosis in Murine AKR-2B Fibroblasts
| Autor: | Gordon B. Mills, Divaker Choubey, Ruth LaPushin, Hong Ji Xu, Dimpy Koul, Jordan U. Gutterman |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Chromosomal Proteins
Non-Histone Biophysics Gene Expression Apoptosis Endogeny Biology Transfection Biochemistry Cell Line Mice Interferon medicine Animals RNA Antisense Molecular Biology Retinoblastoma Cell growth Intracellular Signaling Peptides and Proteins Nuclear Proteins Cell Biology Fibroblasts Phosphoproteins medicine.disease Culture Media Cell biology DNA-Binding Proteins Cell culture Phosphoprotein Carrier Proteins Tumor Suppressor p53-Binding Protein 1 Cell Division medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 247:379-382 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1998.8804 |
| Popis: | p202 is an interferon (IFN)-inducible, primarily nuclear, phosphoprotein (52-kDa) whose overexpression in transfected cells inhibits colony formation. p202 binds to the retinoblastoma tumor suppressor protein and two other members of the pocket family proteins (p107 and p130). Moreover, overexpression of p202 in transfected cells inhibits the transcriptional activity of E2Fs (E2F-1/DP-1 and E2F-4/DP-1), p53, AP-1 c-Fos and c-Jun, NF-kappaB p50 and p65. Here we demonstrate that inhibition of endogenous p202 production in murine AKR-2B fibroblasts did not result in an increase in cell proliferation. Instead, these cells exhibited increased susceptibility to apoptosis in response to decrease in serum concentrations in the growth medium. These observations are consistent with the notion that normal levels of p202 may be needed for the regulation of cell proliferation. |
| Databáze: | OpenAIRE |
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