Ocular surface evaluation in patients treated with a fixed combination of prostaglandin analogues with 0.5% timolol maleate topical monotherapy: a randomized clinical trial
| Autor: | Fabiano Montiani-Ferreira, José Álvaro Pereira Gomes, Heloisa Helena Abil Russ, Nubia Vanessa Lima de Faria, Pedro Antonio Nogueira-Filho, Jeison de Nadai Barros, Paulo Augusto de Arruda Mello |
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| Jazyk: | angličtina |
| Předmět: |
Male
Intraocular pressure genetic structures Timolol Ocular hypertension Glaucoma Eye chemistry.chemical_compound Travoprost Prostaglandins Synthetic Single-Blind Method Ocular Surface Disease Index Prospective Studies Latanoprost lcsh:R5-920 treatment Cloprostenol General Medicine Clinical Science Middle Aged Immunohistochemistry Drug Combinations Treatment Outcome Anesthesia Prostaglandins F Synthetic immunohistochemistry Female lcsh:Medicine (General) Conjunctiva Glaucoma Open-Angle medicine.drug medicine.medical_specialty conjunctiva Ophthalmology medicine Humans Antihypertensive Agents Aged Inflammation Bimatoprost Interleukin-6 business.industry HLA-DR Antigens medicine.disease Amides eye diseases Treatment glaucoma chemistry inflammation Ocular Hypertension sense organs business |
| Zdroj: | Clinics, Vol 68, Iss 10, Pp 1318-1324 Clinics, Volume: 68, Issue: 10, Pages: 1318-1324, Published: OCT 2013 Clinics; v. 68 n. 10 (2013); 1318-1324 Clinics; Vol. 68 Núm. 10 (2013); 1318-1324 Clinics; Vol. 68 No. 10 (2013); 1318-1324 Clinics Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: To compare ocular surface changes induced via glaucoma treatment in patients using fixed combinations of prostaglandin analogues (travoprost, latanoprost and bimatoprost) with 0.5% timolol maleate METHODS: A prospective, multicenter, randomized, parallel group, single-blind clinical trial was performed in 33 patients with ocular hypertension or open angle glaucoma who had not been previously treated. The ocular surface was evaluated prior to and three months after treatment, with a daily drop instillation of one of the three medications. The main outcome measurements included the tear film break-up time, Schirmer's test, Lissamine green staining, the Ocular Surface Disease Index questionnaire, impression cytology using HE and PAS and immunocytochemistry for interleukin-6 and HLA-DR. Ensaiosclinicos.gov.br: UTN - U1111-1129-2872 RESULTS: All of the drugs induced a significant reduction in intraocular pressure. Decreases in the Schirmer's test results were observed with all of the drugs. Decreases in tear-film break-up time were noted with travoprost/timolol and latanoprost/timolol. An increase in the Lissamine green score was noted with travoprost/timolol and bimatoprost/timolol. The Ocular Surface Disease Index score increased after treatment in the travoprost/timolol group. Impression cytology revealed a significant difference in cell-to-cell contact in the same group, an increase in cellularity in all of the groups and an increase in the number of goblet cells in all of the groups. The fixed combinations induced an increase in IL-6 expression in the travoprost/timolol group, in which there was also an increase in HLA-DR expression. CONCLUSIONS: All of the fixed combinations induced a significant reduction in intraocular pressure, and the travoprost/timolol group showed increased expression of the inflammatory markers HLA-DR and interleukin-6. All three tested medications resulted in some degree of deterioration in the ocular surface after three months of glaucoma treatment. |
| Databáze: | OpenAIRE |
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