Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: A systematic review
| Autor: | Francisca Idalina Neta, Luciana Cristina Borges Fernandes, Ianara Mendonça da Costa, Irami Araújo Filho, Eduardo Pereira de Azevedo, Francisca Overlânia Vieira Lima, Fausto Pierdoná Guzen, José Rodolfo Lopes de Paiva Cavalcanti, Eudes Euler de Souza Lucena, Amália Cínthia Meneses Rêgo, Marco Aurelio M. Freire |
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| Rok vydání: | 2018 |
| Předmět: |
Levodopa
Parkinson's disease Ayurvedic medicine Plant Science Disease Pharmacology Cochrane Library 030226 pharmacology & pharmacy 01 natural sciences Neuroprotection 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine biology business.industry Mucuna pruriens (L.) DC medicine.disease biology.organism_classification Electronic library 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Parkinson’s disease Antioxidant business Mucuna pruriens medicine.drug |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| ISSN: | 0973-7847 |
| DOI: | 10.4103/phrev.phrev_46_17 |
| Popis: | Introduction: Mucuna pruriens (L.)DC. (Mp) has been used in the treatment of numerous diseases in Indian Ayurvedic medicine, mainly for delaying the symptoms of Parkinson's disease (PD), and has as its main component levodopa (L-DOPA). The aim of this work is to systematically review the effects of Mp supplementation on experimental models of PD due to its neuroprotective and antioxidant properties. MATERIALS AND Methods: The search was conducted through PubMed, ScienceDirect, Cochrane Library, and Scientific Electronic Library Online databases, where a number of relevant articles were found. Results: Mp demonstrated significant positive responses in the experimental models of PD by improving motor deficits and by enhancing the activity of the antioxidant systems, reducing oxidative stress. In addition, it presented some advantages when compared to a conventional antiparkinsonian drug as it minimized the occurrence and severity of dyskinesias. Conclusion: Thus, considering that the use of herbal medicines decreases the likelihood of side effects associated with the pharmaceutical drugs, this work aims to summarize and evaluate the data available regarding the mechanism of action of Mp and the reported benefits of this plant as an alternative to improve the quality of life of individuals with PD. |
| Databáze: | OpenAIRE |
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