Serum phosphate is associated with mortality among patients admitted to ICU for acute pancreatitis

Autor: Gaël Piton, Sophie Grabar, Chérifa Cheurfa, Abdellah Hedjoudje, Emmanuel Weiss, Dilhana Badurdeen, Philippe Lévy, Frédéric Prat, Vivek Kumbhari, Jad Farha
Přispěvatelé: Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Johns Hopkins Hospital, Hôpital Cochin [AP-HP], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), HAL-SU, Gestionnaire, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
Rok vydání: 2021
Předmět:
Male
Multivariate analysis
pancreatitis
Anion gap
law.invention
Leukocyte Count
Patient Admission
0302 clinical medicine
Reference Values
law
risk factors
Prospective cohort study
Acid-Base Equilibrium
Hazard ratio
Gastroenterology
Middle Aged
Intensive care unit
3. Good health
Intensive Care Units
Oncology
030220 oncology & carcinogenesis
Acute Disease
Acute pancreatitis
Female
Original Article
030211 gastroenterology & hepatology
Adult
medicine.medical_specialty
Sensitivity and Specificity
Phosphates
03 medical and health sciences
Internal medicine
medicine
Humans
serum phosphate
Pancreas
Aged
Proportional Hazards Models
Retrospective Studies
business.industry
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Bilirubin
Serum phosphate
Alkaline Phosphatase
medicine.disease
mortality
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
ROC Curve
Potassium
serum phospahte
Pancreatitis
Calcium
business
Biomarkers
Zdroj: United European Gastroenterology Journal
United European Gastroenterology Journal, SAGE Publications, In press, ⟨10.1002/ueg2.12059⟩
ISSN: 2050-6414
2050-6406
DOI: 10.1002/ueg2.12059
Popis: Background and Aims Routine laboratory tests can be useful predictors in the early assessment of the severity and mortality of acute pancreatitis (AP). The aim of this study was to evaluate the accuracy of clinical and laboratory parameters for the prediction of mortality among patients admitted to the intensive care unit (ICU) for AP. Methods We conducted a retrospective analysis of prospectively collected data from Beth Israel Deaconess Hospital made publicly available to examine the relationship between routine clinical and laboratory parameters with respect to mortality for AP. Cox proportional hazard ratio was used to evaluate the impact of several routine laboratory markers on mortality. Receiver operation characteristic (ROC) curve was performed to determine the accuracy of diagnosis of laboratory tests by using area under curve (AUC) for the respective analysis. Results In total, 499 patients were admitted to the ICU for AP. Several factors for predicting mortality in AP at admission were identified in the multivariate analysis: alkaline phosphatase hazard ratio (HR) = 1.00 (1.00–1.00, p = 0.024), anion gap HR = 1.09 (1.00–1.20, p = 0.047), bilirubin total HR = 1.11 (1.06–1.17, p
Key Points This is the first study that evaluates the role of serum phosphate at baseline for predicting the mortality of acute pancreatitis (AP) in intensive care unit (ICU).This study found that serum phosphate is a useful laboratory marker for predicting the mortality of AP independently of other known factors.This study found that serum phosphate value greater than 3.78 mg/dl within the first 24 h after admission in the ICU could predict mortality (area under curve = 0.7, p
Databáze: OpenAIRE
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