Could vitamin D deficiency have an impact on motor and cognitive function in Parkinson’s disease?

Autor:	Mona Hussein, Rasha H. Soliman, Sara Mostafa, Sanaa Abd El-Shafy, Mohammed I. Oraby
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	medicine.medical_specialty Parkinson's disease Neurology vitamin D deficiency lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Rating scale Internal medicine Epidemiology Vitamin D and neurology Medicine Verbal fluency test 030212 general & internal medicine PD-CRS Vitamin D lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry UPDRS business.industry General Neuroscience Cognition medicine.disease Psychiatry and Mental health Parkinson’s disease Surgery Neurology (clinical) Pshychiatric Mental Health business 030217 neurology & neurosurgery
Zdroj:	The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 55, Iss 1, Pp 1-6 (2019)
ISSN:	1687-8329
DOI:	10.1186/s41983-019-0084-9
Popis:	Background Multiple epidemiological data showed a significant higher prevalence of hypovitaminosis D in patients with Parkinson’s disease (PD). Objectives To assess the serum vitamin D level in patients with Parkinson’s disease and to investigate the possible relationship between the serum vitamin D level and both motor and cognitive symptoms in Parkinson’s disease Materials and methods A case-control study was conducted on 25 patients who fulfilled the criteria for diagnosis of idiopathic Parkinson’s disease based on the British Brain Bank criteria, and 25 healthy volunteers. Selected PD patients were submitted for assessment of cognitive function using the PD - Cognitive Rating Scale (PD-CRS) and assessment of motor function using the Unified Parkinson’s Disease Rating Scale (UPDRS). Serum 25 hydroxy vitamin D level was measured for all the included patients and controls. Results PD patients were found to have a significantly lower level of serum vitamin D than controls (P value = 0.001). There was a statistically significant negative correlation between the serum vitamin D level and the scores of motor, mentation, activities of daily living, medication complication, other complications, and the total score of UPDRS (P value = 0.01
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56afa049de25f7fc0ba368d308fd0dfc http://link.springer.com/article/10.1186/s41983-019-0084-9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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