Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity
| Autor: | Mikael Rydén, Erik Arner, Daniel P. Andersson, Anders Thorell, M. Palmer, Eva Toft, P. Löfgren, Peter Arner, Johan Hoffstedt, Veronica Qvisth, Anders Thörne, Hans Wahrenberg, Mikael Wirén |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism Subcutaneous Fat Blood sugar Adipose tissue Blood lipids Inflammation Intra-Abdominal Fat Biology Young Adult chemistry.chemical_compound Adipocyte Internal medicine Diabetes mellitus Adipocytes Internal Medicine medicine Humans Insulin Triglycerides Apolipoproteins B Cell Size Middle Aged medicine.disease Obesity Obesity Morbid Endocrinology Adipose Tissue chemistry Glucose Clamp Technique Metabolome Female medicine.symptom Body mass index |
| Zdroj: | Diabetologia. 53:2496-2503 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s00125-010-1889-3 |
| Popis: | The aim of this study was to determine whether the mean size of fat cells in either visceral or subcutaneous adipose tissue has an impact on the metabolic and inflammatory profiles in morbid obesity.In 80 morbidly obese women, mean visceral (omental) and subcutaneous fat cell sizes were related to in vivo markers of inflammation, glucose metabolism and lipid metabolism.Visceral, but not subcutaneous, adipocyte size was significantly associated with plasma apolipoprotein B, total cholesterol, LDL-cholesterol and triacylglycerols (p ranging from 0.002 to 0.015, partial r ranging from 0.3 to 0.4). Subcutaneous, but not visceral, adipocyte size was significantly associated with plasma insulin and glucose, insulin-induced glucose disposal and insulin sensitivity (p ranging from 0.002 to 0.005, partial r ranging from -0.34 to 0.35). The associations were independent of age, BMI, body fat mass or body fat distribution. Adipose tissue hyperplasia (i.e. many small adipocytes) in both regions was significantly associated with better glucose, insulin and lipid profiles compared with adipose hypertrophy (i.e. few large adipocytes) in any or both regions (p ranging from0.0001 to 0.04). Circulating inflammatory markers were not associated with fat cell size or corresponding gene expression in the fat cell regions examined.In morbidly obese women region-specific variations in mean adipocyte size are associated with metabolic complications but not systemic or adipose inflammation. Large fat cells in the visceral region are linked to dyslipidaemia, whereas large subcutaneous adipocytes are important for glucose and insulin abnormalities. Hyperplasia (many small adipocytes) in both adipose regions may be protective against lipid as well as glucose/insulin abnormalities in obesity. |
| Databáze: | OpenAIRE |
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