lncRNA MNX1-AS1 Promotes Glioblastoma Progression Through Inhibition of miR-4443
| Autor: | Jue Wang, Lulu Wen, Yan Gao, Juan Feng, Yongchuan Xu, Xue Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
miR-4443 Cancer Research Proliferation Biology urologic and male genital diseases Article 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Movement Glioblastoma (GBM) Cell Line Tumor Humans Neoplasm Invasiveness Migration Cell Proliferation Regulation of gene expression Homeodomain Proteins Gene knockdown Oncogene Cell growth urogenital system RNA General Medicine female genital diseases and pregnancy complications nervous system diseases Up-Regulation Gene Expression Regulation Neoplastic MNX1-AS1 MicroRNAs 030104 developmental biology Oncology Cell culture 030220 oncology & carcinogenesis Cancer research Disease Progression RNA Long Noncoding Glioblastoma Function (biology) Transcription Factors |
| Zdroj: | Oncology Research |
| ISSN: | 1555-3906 0965-0407 |
| Popis: | Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. lncRNA MNX1-AS1 has been shown to be an oncogene in epithelial ovarian cancer. However, the function of MNX1-AS1 in glioblastoma (GBM) remains largely unknown. Here we found that the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. Knockdown of MNX1-AS1 significantly inhibited the proliferation, migration, and invasion of GBM cells. In terms of mechanism, we found that MNX1-AS1 could bind to miR-4443 in GBM cells. Overexpression of miR-4443 significantly inhibited the expression of MNX1-AS1 and vice versa. Moreover, there was an inverse correlation between the expression levels of MNX1-AS1 and miR-4443 in GBM tissues. We found that overexpression of miR-4443 inhibited the proliferation, migration, and invasion of GBM cells. We also showed that inhibition of miR-4443 reversed the effects of MNX1-AS1 knockdown on GBM cell proliferation, migration, and invasion. Taken together, we found that MNX1-AS1 promoted the proliferation, migration, and invasion of GBM cells through inhibiting miR-4443. |
| Databáze: | OpenAIRE |
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