Research on the balance of thiol-disulfide in blood serum in women with telogen effluvium
| Autor: | Fadime Kilinç, Sertac Sener, Orhan Şen, Cemile Bıçer, Ayşe Akbaş, Akta Akınş |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Disulfide exchange Chemistry medicine.medical_treatment Statistical difference Dermatology medicine.disease_cause medicine.disease Telogen effluvium thiol–disulfide balance 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Hair loss Blood serum Biochemistry Oxidative stress 030220 oncology & carcinogenesis medicine Thiol Original Article telogen effluvium |
| Zdroj: | International Journal of Trichology |
| ISSN: | 0974-7753 |
| DOI: | 10.4103/ijt.ijt_78_17 |
| Popis: | Backgrounds: Telogen effluvium (TE) is the most common reason for hair loss in humans. Although the exact etiopathogenesis of TE has not been revealed clearly and completely, multifactorial etiologies are to be blamed. In recent years, since oxidative stress (OS) has been shown to play an important role in the etiopathogenesis of so many diseases, the effects of OS on several skin diseases are researched and analyzed. Thiols are antioxidant components that include sulfur group, and the balance of thiol-disulfide has an important role in the formation and prevention of OS. This balance is destroyed in many diseases and its effect on TE is not clearly understood yet. Objectives: In this study, we aimed to search the thiol–disulfide balance that could reveal OS in patients with TE. Materials and Methods: Fifty-two patients with TE and control group of 46 persons were included in the study. Native thiol, disulfide, and total thiol levels were evaluated by a new, automatic spectrophotometric method. Disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol rates were calculated. Results: There was no statistical difference between TE patients and control group in terms of native thiol, disulfide, and total thiol levels. Thiol–disulfide balance was fixed and not affected in TE patients. |
| Databáze: | OpenAIRE |
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