Potential role of biofilms in deep cervical abscess
| Autor: | Mark Micale, Anthony Sheyn, James M. Coticchia, Priyanka Shah, Gregory J. Kruper, Jason G. May, Livjot Sachdeva |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent medicine.drug_class Antibiotics Bacterial Physiological Phenomena Polymicrobial biofilms Young Adult Biopsy Humans Medicine Child Abscess medicine.diagnostic_test business.industry Biofilm Infant General Medicine Retropharyngeal Abscess medicine.disease Otorhinolaryngology Biofilms Child Preschool Electron micrographs Pediatrics Perinatology and Child Health Microscopy Electron Scanning Female business Neck Life-threatening infections Cervical abscess |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 78:10-13 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2013.09.009 |
| Popis: | Objectives Deep neck abscesses are complex head & neck problems that can lead to significant complications including life threatening infections. It is understood that the pathology of these infections is primarily polymicrobial. Although broad spectrum antibiotics can be effective for small abscesses, larger abscesses can be recalcitrant and difficult to treat with antibiotics. It has been demonstrated for several infectious diseases, including some of head & neck, that biofilm phenotypes present a unique model for recurrence and chronicity of infectious diseases. It is suspected that biofilm phenotypes could play a crucial role in the recalcitrance of large deep neck abscesses. This study presents initial evidence indicating the presence of polymicrobial biofilms in deep neck space infections. Methods Fourteen samples obtained via biopsy of abscess walls from deep neck spaces of patients undergoing surgical drainage. Eight patients were male and 6 were female. All but one patient were pediatric with ages ranging from 18 months to 32 years. All samples were processed and analyzed with scanning electron microscopy. Results Electron micrographs of 12 out of 14 specimens showed discrete biofilm architecture with individual bacteria, both rods and cocci, embedded within the matrix. This was starkly different from tissue surfaces devoid of biofilms. Conclusions This initial evidence suggests that biofilm phenotypes could play a role in the pathogenesis and recalcitrance of deep neck infections, particularly in larger abscesses. |
| Databáze: | OpenAIRE |
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