The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia
| Autor: | Chunrong Pang, Xiaohong Wei, Ting Hou, Benlan Yin, Yujiao Zhang, Yuzhi Ning, Chao Yang, Xiaodong Fu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Science Late onset macromolecular substances 030204 cardiovascular system & hematology Article Umbilical Arteries Immunological techniques 03 medical and health sciences 0302 clinical medicine KATP Channels Pre-Eclampsia Pregnancy Internal medicine medicine Humans RNA Messenger reproductive and urinary physiology Messenger RNA Multidisciplinary Eclampsia business.industry medicine.disease Potassium channel female genital diseases and pregnancy complications Normal group Blot Real-time polymerase chain reaction Endocrinology Cardiovascular diseases nervous system Gene Expression Regulation embryonic structures Medicine Female business 030217 neurology & neurosurgery Occurrence time |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2045-2322 |
| Popis: | The aim of this study is to establish the expression of ATP-sensitive potassium channels(KATP) in human umbilical arteries with severe pre-eclampsia. Real-time quantitative PCR and western blotting were used to detect the mRNA and protein expression levels of KATP channel subunits Kir6.1 and SUR2B in human umbilical arteries from normal pregnant and those with severe pre-eclampsia, early onset severe pre-eclampsia and late onset severe pre-eclampsia. The mRNA and protein levels of SUR2B in the severe pre-eclampsia group were lower than those in the normal group (P P > 0.05). The mRNA and protein levels of SUR2B in early onset severe pre-eclampsia group were lower than those in late onset severe pre-eclampsia group (P P > 0.05). The mRNA and protein expression levels of SUR2B in pregnant women with severe pre-eclampsia were lower than those in normal pregnant women, suggesting that the expression of the SUR2B of the KATP channel may be related to the occurrence and development of severe pre-eclampsia. Compared with late onset severe pre-eclampsia, the mRNA and protein expression levels of SUR2B were lower in the umbilical arteries of women with early onset severe pre-eclampsia, suggesting that the occurrence time of severe pre-eclampsia may be related to the extent reduced expression of the SUR2B of the KATP channel. |
| Databáze: | OpenAIRE |
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