Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19
Autor: | Tobias, Geis, Susanne, Brandstetter, Antoaneta A, Toncheva, Otto, Laub, Georg, Leipold, Ralf, Wagner, Michael, Kabesch, Severin, Kasser, Jens, Kuhle, Sven, Wellmann, Stephan, Gerling |
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Rok vydání: | 2021 |
Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Neurology Population 610 Medizin Intermediate Filaments Neurofilament Asymptomatic 03 medical and health sciences 0302 clinical medicine Neurofilament Proteins Internal medicine Humans Medicine Child education Children ddc:610 education.field_of_study Original Communication biology medicine.diagnostic_test SARS-CoV-2 business.industry COVID-19 Brain COVID-19 Children Brain Neurology Neurofilament Systemic Inflammatory Response Syndrome Cross-Sectional Studies 030104 developmental biology Immunoassay Cohort biology.protein Population study Biomarker (medicine) Neurology (clinical) medicine.symptom Antibody business 030217 neurology & neurosurgery |
Zdroj: | Journal of Neurology |
ISSN: | 1432-1459 0340-5354 |
Popis: | Background Serum neurofilament light chain (sNfL) is an established biomarker of neuro-axonal damage in multiple neurological disorders. Raised sNfL levels have been reported in adults infected with pandemic coronavirus disease 2019 (COVID-19). Levels in children infected with COVID-19 have not as yet been reported. Objective To evaluate whether sNfL is elevated in children contracting COVID-19. Methods Between May 22 and July 22, 2020, a network of outpatient pediatricians in Bavaria, Germany, the Coronavirus antibody screening in children from Bavaria study network (CoKiBa), recruited healthy children into a cross-sectional study from two sources: an ongoing prevention program for 1–14 years, and referrals of 1–17 years consulting a pediatrician for possible infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We determined sNfL levels by single molecule array immunoassay and SARS-CoV-2 antibody status by two independent quantitative methods. Results Of the 2652 included children, 148 (5.6%) were SARS-CoV-2 antibody positive with asymptomatic to moderate COVID-19 infection. Neurological symptoms—headache, dizziness, muscle aches, or loss of smell and taste—were present in 47/148 cases (31.8%). Mean sNfL levels were 5.5 pg/ml (SD 2.9) in the total cohort, 5.1 (SD 2.1) pg/ml in the children with SARS-CoV-2 antibodies, and 5.5 (SD 3.0) pg/ml in those without. Multivariate regression analysis revealed age—but neither antibody status, antibody levels, nor clinical severity—as an independent predictor of sNfL. Follow-up of children with pediatric multisystem inflammatory syndrome (n = 14) showed no association with sNfL. Conclusions In this population study, children with asymptomatic to moderate COVID-19 showed no neurochemical evidence of neuronal damage. |
Databáze: | OpenAIRE |
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