Modelling the effects of antimicrobial metaphylaxis and pen size on bovine respiratory disease in high and low risk fattening cattle

Autor: Sébastien Picault, Pauline Ezanno, Kristen Smith, David Amrine, Brad White, Sébastien Assié
Přispěvatelé: Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Kansas State University, Institut Carnot France Futur Élevage (F2E) — projet SEPTIME, Région Pays de la Loire (PULSAR), European Project: 101000494,DECIDE
Jazyk: angličtina
Rok vydání: 2022
Předmět:
MESH: Anti-Bacterial Agents / pharmacology
Farms
Epidemiological modelling
Respiratory Tract Diseases
Bovine Respiratory Disease Complex
MESH: Anti-Infective Agents / therapeutic use
[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Anti-Infective Agents
Disease control
Animals
MESH: Animals
Antimicrobial usage
MESH: Bovine Respiratory Disease Complex / diagnosis
Farming practices
MESH: Farms
MESH: Bovine Respiratory Disease Complex / drug therapy
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
General Veterinary
Bovine respiratory disease
MESH: Bovine Respiratory Disease Complex* / prevention & control
MESH: Anti-Infective Agents / pharmacology
[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Anti-Bacterial Agents
Stochastic models
MESH: Cattle
MESH: Respiratory Tract Diseases / veterinary
[INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA]
Cattle
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Anti-Bacterial Agents / therapeutic use
Zdroj: Veterinary Research
Veterinary Research, 2022, 53, pp.1-14. ⟨10.1186/s13567-022-01094-1⟩
ISSN: 0928-4249
1297-9716
DOI: 10.1186/s13567-022-01094-1⟩
Popis: Bovine respiratory disease (BRD) dramatically affects young calves, especially in fattening facilities, and is difficult to understand, anticipate and control due to the multiplicity of factors involved in the onset and impact of this disease. In this study we aimed to compare the impact of farming practices on BRD severity and on antimicrobial usage. We designed a stochastic individual-based mechanistic BRD model which incorporates not only the infectious process, but also clinical signs, detection methods and treatment protocols. We investigated twelve contrasted scenarios which reflect farming practices in various fattening systems, based on pen sizes, risk level, and individual treatment vs. collective treatment (metaphylaxis) before or during fattening. We calibrated model parameters from existing observation data or literature and compared scenario outputs regarding disease dynamics, severity and mortality. The comparison of the trade-off between cumulative BRD duration and number of antimicrobial doses highlighted the added value of risk reduction at pen formation even in small pens, and acknowledges the interest of collective treatments for high-risk pens, with a better efficacy of treatments triggered during fattening based on the number of detected cases.
Databáze: OpenAIRE
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