Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate—A Randomized Controlled Trial
| Autor: | Mette Hansen, Rebekka Thøgersen, Mikkel Oxfeldt, Hanne Christine Bertram, Kathrine Skov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Protein Hydrolysates nutrimetabolomics amino acid absorption lcsh:TX341-641 Hydrolysate Article collagen uptake 03 medical and health sciences Hydroxyproline chemistry.chemical_compound 0302 clinical medicine dietary protein collagen nutriceuticals Enzymatic hydrolysis Internal medicine medicine Humans hydroxyproline Proline Hydrolyzed collagen Amino Acids proline 030109 nutrition & dietetics Nutrition and Dietetics Cross-Over Studies Chemistry Hydrolysis 030229 sport sciences Postprandial Period Bioavailability Endocrinology Postprandial sports nutrition collagen absorption Glycine Collagen lcsh:Nutrition. Foods and food supply Food Science glycine |
| Zdroj: | Nutrients, Vol 11, Iss 5, p 1064 (2019) Skov, K, Oxfeldt, M, Thøgersen, R, Hansen, M & Bertram, H C 2019, ' Enzymatic hydrolysis of a collagen hydrolysate enhances postprandial absorption rate-a randomized controlled trial ', Nutrients, vol. 11, no. 5, 1064 . https://doi.org/10.3390/nu11051064 Nutrients Volume 11 Issue 5 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11051064 |
| Popis: | Collagen is characterized by its high content of glycine, proline and hydroxyproline, and is found to exert beneficial effects on joint pain related to activity and osteoarthritis. However, to exert any beneficial effects it is essential that collagen is optimally absorbed. This study aimed to investigate the postprandial absorption of collagen and elucidate the impact of an exogenous enzymatic hydrolysis on absorption rate and bioavailability. A randomized, blinded, cross-over study was conducted where ten healthy male subjects received either 35 g enzymatically hydrolyzed collagen protein (EHC), 35 g non-enzymatically hydrolyzed collagen protein (NC) or placebo (250 mL water) on three nonconsecutive days. Blood samples were drawn before, and up to 240 min following, ingestion and the blood metabolome was characterized by nuclear magnetic resonance (NMR)-based metabolomics. A significant increase in the plasma concentration of nearly all amino acids (AAs) was observed over a 240 min period for both EHC and NC. In addition, the absorption rate and bioavailability of glycine, proline and hydroxyproline were significantly higher for EHC (p < 0.05). In conclusion, ingestion of collagen hydrolysates increases postprandial plasma concentrations of AAs over a period of 240 min, and an enzymatic hydrolysis increases the absorption rate and bioavailability of the collagen-rich AAs glycine, proline and hydroxyproline. |
| Databáze: | OpenAIRE |
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