The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage
| Autor: | Valeriya Laskova, Jyothsna Chitturi, Mei Ding, Wei Wang, Xia Li, Mei Zhen, Qinglan Ge, Xun Huang, Jinbo Wang |
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| Rok vydání: | 2014 |
| Předmět: |
Cell type
Cell division Neurite Cell Apoptosis medicine Neurites Animals Progenitor cell Caenorhabditis elegans Caenorhabditis elegans Proteins Molecular Biology Transcription factor Histone Acetyltransferases biology fungi Gene Expression Regulation Developmental Histone acetyltransferase biology.organism_classification Molecular biology Cell biology Repressor Proteins medicine.anatomical_structure nervous system biology.protein human activities Developmental Biology Protein Binding Transcription Factors |
| Zdroj: | Development (Cambridge, England). 142(8) |
| ISSN: | 1477-9129 |
| Popis: | Mechanisms that regulate apoptosis in a temporal and lineage-specific manner remain poorly understood. The COE (Collier/Olf/EBF) transcription factors have been implicated in the development of many cell types, including neurons. Here, we show that the sole Caenorhabditis elegans COE protein, UNC-3, together with a histone acetyltransferase, CBP-1/P300, specifies lineage-specific apoptosis and certain aspects of neurite trajectory. During embryogenesis, the RID progenitor cell gives rise to the RID neuron and RID sister cell; the latter undergoes apoptosis shortly after cell division upon expression of the pro-apoptotic gene egl-1. We observe UNC-3 expression in the RID progenitor, and the absence of UNC-3 results in the failure of the RID lineage to express a Pegl-1::GFP reporter and in the survival of the RID sister cell. Lastly, UNC-3 interacts with CBP-1, and cbp-1 mutants exhibit a similar RID phenotype to unc-3. Thus, in addition to playing a role in neuronal terminal differentiation, UNC-3 is a cell lineage-specific regulator of apoptosis. |
| Databáze: | OpenAIRE |
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