Waiting list removal rates among patients with chronic and malignant liver diseases
| Autor: | Richard B. Freeman, Ann M. Harper, E. B. Edwards |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcoholic liver disease Carcinoma Hepatocellular Tissue and Organ Procurement Adolescent Waiting Lists medicine.medical_treatment Liver transplantation Gastroenterology Severity of Illness Index Liver disease Internal medicine Severity of illness Carcinoma medicine Immunology and Allergy Humans Pharmacology (medical) Transplantation Framingham Risk Score Health Care Rationing business.industry Liver Diseases Liver Neoplasms Cancer Middle Aged medicine.disease United States Surgery Liver Transplantation Female business Liver Failure |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 6(6) |
| ISSN: | 1600-6135 |
| Popis: | Equitable liver allocation should ensure that nonelective removal rates are fairly distributed among waiting candidates. We compared removal rates for adults entered with nonmalignant (NM) (N = 9379) and hepatocellular cancer (HCC) (N = 2052) diagnoses on the Organ Procurement and Transplantation Network (OPTN) list between April 30, 2003, and December 31, 2004. Unadjusted removal rates for NM vs. HCC diagnoses were 9.4% vs. 8.7%, 13.5% vs. 16.9% and 19.1% vs. 31.8% at 90, 180 and 365 days, respectively after listing. For NM candidates, model for end-stage liver disease (MELD) score (RR = 1.16), age (RR = 1.03) and metabolic disease diagnoses (RR = 1.66) had higher risks of removal; and PSC (RR = 0.62) and alcoholic cirrhosis (RR = 0.82) had lower risks of removal. For HCC candidates, MELD score at listing (RR = 1.09), AFP (RR = 1.02), maximum tumor size (RR = 1.16) and age at listing (RR = 1.02) had increased risks of removal. The equation 1 - 0.920 exp[0.09369 (MELD at listing - 12.48) + 0.00193 (AFP - 97.4) + 0.1505 (maximum tumor size - 2.59) defined the probability of dropout for HCC candidates within 90 days of listing. We conclude that factors associated with the risk of removal for HCC are different from NM candidates, although MELD score at listing remains the most predictive for both groups. Liver transplant candidates with HCC may be prioritized using a risk score analogous to the MELD score. |
| Databáze: | OpenAIRE |
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