Levonorgestrel-releasing and copper intrauterine devices and the risk of breast cancer
| Autor: | Kristina Bardenheuer, Jürgen Dinger, Thai Do Minh |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Population Breast Neoplasms Levonorgestrel Breast cancer Germany Surveys and Questionnaires Medicine Humans Risk factor education Finland Retrospective Studies Gynecology education.field_of_study business.industry Intrauterine Devices Medicated Obstetrics and Gynecology Cancer Retrospective cohort study Middle Aged medicine.disease Intrauterine Devices Copper Logistic Models Reproductive Medicine Relative risk Case-Control Studies Female Breast disease business medicine.drug |
| Zdroj: | Contraception. 83(3) |
| ISSN: | 1879-0518 |
| Popis: | Background This study compares the risk of breast cancer for levonorgestrel-releasing intrauterine devices (LNG IUD ) versus copper IUDs (CU IUD ) in women younger than 50 years of age. Study Design Retrospective, population-based, case-control study using cancer registers in Finland and Germany, powered to exclude a 1.5-fold risk of breast cancer. Results Analysis of 5113 breast cancer cases diagnosed 2000���2007 and 20,452 controls ��� matched by year of birth and area of residence ��� yielded relative risk estimates approaching unity with 95% CI crossing 1.0 for all comparisons, including ever-use of LNG IUD versus CU IUD (adjusted OR, 0.99; 95% CI, 0.88���1.12) and current use at time of diagnosis (adjusted OR, 0.85; 95% CI, 0.52���1.39), as well as for sub-analyses by country, age, tumor characteristics and period, recency and duration of use prior to diagnosis. Conclusion This study does not indicate an increased risk of breast cancer for users of LNG IUD . No indications for tumor promotion or tumor induction were found. |
| Databáze: | OpenAIRE |
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