Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus
| Autor: | Lilian Vera, Marcela Ferrés, Marcelo López-Lastra, Claudia Marco, Héctor Galeno, Jenniffer Angulo, Andrea Bermúdez, Eliecer Villagra, Constanza Martínez-Valdebenito, Judith Mora, Natalia Lagos, Natalia Becerra, Janepsy Díaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male RNA viruses Orthohantavirus Pulmonology Physiology Andes virus Pathology and Laboratory Medicine Gastroenterology Severity of Illness Index Geographical locations Risk Factors Immune Physiology Bunyaviruses Medicine and Health Sciences Young adult Chile Child Aged 80 and over Innate Immune System biology Headaches lcsh:Public aspects of medicine Middle Aged Hospitals Infectious Diseases Medical Microbiology Child Preschool Viral Pathogens Viruses Disease Progression Cytokines Female Pathogens Research Article Hantavirus Adult medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine Adolescent Infectious Disease Control lcsh:RC955-962 030106 microbiology Immunology Hantavirus Pulmonary Syndrome Microbiology 03 medical and health sciences Young Adult Age Distribution Signs and Symptoms Diagnostic Medicine Internal medicine Severity of illness medicine Humans Sex Distribution Interleukin 6 Microbial Pathogens Aged Hantavirus pulmonary syndrome Chile (Country) business.industry Interleukin-6 Andes Virus Public Health Environmental and Occupational Health Case-control study Infant Newborn Organisms Infant Biology and Life Sciences lcsh:RA1-1270 Molecular Development South America Surgery Health Care 030104 developmental biology Logistic Models Health Care Facilities Case-Control Studies Immune System Multivariate Analysis Respiratory Infections Etiology biology.protein People and places business Developmental Biology |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005757 (2017) PLoS Neglected Tropical Diseases |
| ISSN: | 1935-2735 1935-2727 |
| Popis: | Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circulating cytokines were determined by a Bead-Based Multiplex assay coupled with Luminex detection technology, in order to compare 43 serum samples of healthy controls and 43 samples of ANDV-infected patients that had been categorized according to the severity of disease. When compared to the controls, no significant differences in IL-1β concentration were observed in ANDV-infected patients (p = 0.9672), whereas levels of IL-12p70 and IL-21 were significantly lower in infected cases (p = Author summary Andes virus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS) that is characterized by the development of vascular leakage syndrome, eventually leading to massive pulmonary edema, shock and, in many cases, death. To date, no FDA-approved immunotherapeutics, specific antivirals, or vaccines are available for use against HCPS. Patient survival rates hinge largely on early virus diagnosis, hospital admission and aggressive pulmonary and hemodynamic support in an intensive care unit. Individual host factors associated with the outcome of an ANDV infection are poorly known, and such knowledge could allow the disease progression of hospitalized patients to be predicted, resulting in individualized treatment. In this study, we show that serum levels of IL-6 at the time of hospitalization in ANDV-infected patients are associated with the severity of the clinical outcome of ANDV-induced disease. Therefore, these finding suggest that determining IL-6 levels at the time of admission to the hospital could be useful to predict the progression of ANDV-induced disease. |
| Databáze: | OpenAIRE |
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