Association ofADIPOR2With Liver Function Tests in Type 2 Diabetic Subjects
| Autor: | Patricia Botas-Cervero, Abel López-Bermejo, Elías Delgado, Tohru Funahashi, Francisco Ortega-Delgado, José Manuel Fernández-Real, Wifredo Ricart, Maria García-Gil |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Medicine (miscellaneous) Single-nucleotide polymorphism Type 2 diabetes Polymorphism Single Nucleotide Endocrinology Insulin resistance Liver Function Tests Internal medicine Humans Medicine Aspartate Aminotransferases Receptor education Aged education.field_of_study Nutrition and Dietetics Adiponectin medicine.diagnostic_test business.industry Liver Diseases Alanine Transaminase Middle Aged medicine.disease Obesity Cross-Sectional Studies Diabetes Mellitus Type 2 Liver Spain Multivariate Analysis Female Insulin Resistance Receptors Adiponectin business Liver function tests |
| Zdroj: | Obesity. 16:2308-2313 |
| ISSN: | 1930-7381 |
| DOI: | 10.1038/oby.2008.344 |
| Popis: | Objective: Adiponectin protects against liver dysfunction in insulin-resistant states such as obesity and type 2 diabetes (T2DM), but the role of adiponectin receptors in this disorder is largely unknown. We studied whether common single-nucleotide polymorphisms (SNPs) in ADIPOR1 and ADIPOR2 are associated with liver function tests (LFTs) in human subjects with various degrees of insulin resistance. Methods and Procedures: Serum alanine (ALT) and aspartate (AST) aminotransferases, homeostasis model assessment of insulin resistance (HOMA-IR), −8503 G/A (rs6666089) and +5843 C/T (rs1342387) SNPs in ADIPOR1, −64,241 T/G (rs1029629) and +33447 C/T (rs1044471) SNPs in ADIPOR2 were assessed in 700 white subjects from a population-based study. Results: In nondiabetic subjects, the at-risk alleles for the common −64,241 T/G and +33447 C/T SNPs in ADIPOR2 were associated with increased circulating adiponectin (P < 0.05 to P < 0.005), but not with LFT. Conversely, in T2DM subjects (who are at risk for liver dysfunction), the same alleles were associated with increased serum ALT and AST (P < 0.05 to P < 0.0001), but not with circulating adiponectin. No significant associations with these parameters were evident for the common −8503 G/A and +5843 C/T SNPs in ADIPOR1. In a replication study, the −64,241 T/G and +33447 C/T SNPs in ADIPOR2 were associated with ALT and AST (P < 0.05 to P < 0.0001) in pooled obese and T2DM subjects. Discussion: Common SNPs in ADIPOR2 are associated with LFT in T2DM subjects, which suggests a possible role of this receptor in liver dysfunction associated with insulin resistance. |
| Databáze: | OpenAIRE |
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