Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study
| Autor: | Juergen E. Scherberich, Andreas Lechner, Cornelia Then, Holger Then, Barbara Thorand, Wolfgang Rathmann, Wolfgang Koenig, Christa Meisinger, Martin Bidlingmaier, Margit Heier, Martin Reincke, Jochen Seissler, Annette Peters |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Prohormone Myocardial Infarction 030232 urology & nephrology Blood Pressure 030204 cardiovascular system & hematology Vascular Medicine Biochemistry chemistry.chemical_compound Mathematical and Statistical Techniques 0302 clinical medicine Renin Medicine and Health Sciences Lipid Hormones Myocardial infarction Aldosterone Stroke education.field_of_study Multidisciplinary Endothelin-1 Organic Compounds Monosaccharides Statistics Chemistry Hypertension Physical Sciences Cardiology Regression Analysis Medicine Female Anatomy Research Article medicine.drug medicine.medical_specialty Science Population Carbohydrates Linear Regression Analysis Research and Analysis Methods Nephropathy 03 medical and health sciences Internal medicine Uromodulin Renin–angiotensin system medicine Humans ddc:610 Statistical Methods education Aged business.industry Organic Chemistry Chemical Compounds Biology and Life Sciences Kidneys Prohormones Renal System medicine.disease Peptide Fragments Hormones Glucose Blood pressure chemistry business Mathematics |
| Zdroj: | PLoS ONE 15:e0237364 (2020) PLoS ONE, Vol 15, Iss 8, p e0237364 (2020) PLoS ONE |
| Popis: | ObjectivesUromodulin has been associated with arterial hypertension in genome-wide association studies, but data from clinical and preclinical studies are inconsistent. We here analyzed the association of serum uromodulin (sUmod) with arterial hypertension and vasoactive hormones in a population-based study.MethodsIn 1108 participants of the KORA F4 study aged 62-81 years, sUmod was measured and the association of sUmod with arterial hypertension was assessed using logistic regression models. The associations of sUmod with renin and aldosterone and with the vasoconstrictive prohormone C-terminal pro-endothelin-1 (CT-proET-1) were analyzed in 1079 participants and in 618 participants, respectively, using linear regression models.ResultsAfter multivariable adjustment including sex, age, eGFR, BMI, fasting glucose, current smoking, previous stroke and myocardial infarction, sUmod was inversely associated with arterial hypertension (OR 0.78; 95% CI 0.68-0.91; p = 0.001). SUmod was not significantly associated with renin and aldosterone after adjustment for sex, age and eGFR. However, sUmod was inversely associated with CT-proET-1 (β -0.19 ± 0.04; p < 0.001) after adjustment for sex, age, eGFR, BMI, arterial hypertension, fasting glucose, current smoking, previous stroke and myocardial infarction. The association with CT-proET-1 was stronger in participants with hypertension (β -0.22 ± 0.04) than in normotensive participants (β -0.13 ± 0.06; p for interaction hypertension = 0.003 in the model adjusted for hypertension).ConclusionsSUmod was inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1, suggesting direct or indirect effects of sUmod on blood pressure regulation. |
| Databáze: | OpenAIRE |
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