| Autor: |
Mark P. Rubinstein, David J. Cole, Shikhar Mehrotra, Elizabeth Garrett-Mayer, Kevin F. Staveley-O'Carroll, Guangfu Li, Stuart C. Gilreath, Bennett R. May, Brian P. Riesenberg, C. Bryce Johnson |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2326-6066.22537865.v1 |
| Popis: |
Figure S1. Blockade of IL-7 but not IL-2 reduces engraftment of IL-12 conditioned (Tc1) CD8+ T cells in lymphodepleted mice. Figure S2. Blockade of cytokine signaling does not reduce the functionality of donor CD8+ T cells. Figure S3. Activated CD8+ T cells do not require TCR engagement for engraftment in an irradiated host. Figure S4. IL-7 mediated proliferation of Tc1 is STAT5 and PI3K dependent. Figure S5. Tc1 cells generated from IL-7Ralpha+/- and wildtype mice exhibit a similar profile except for IL-7Ralpha expression. Figure S6. The level of TCR stimulation, costimulation, and IL-12 drive IL-7Ralpha expression after CD8+ T cell activation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
