Studies of tantalum dust in the lungs
| Autor: | Paul E. Morrow, Andrea Bianco, Floyd R. Gibb, Robert W. Kilpper, Silviu Landman |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Aerosols
Radioisotopes Pathology medicine.medical_specialty Time Factors Bronchography Inhalation business.industry Radiochemistry Tantalum chemistry.chemical_element respiratory system respiratory tract diseases Dogs chemistry Absolute amount medicine Animals Radiology Nuclear Medicine and imaging Female Biological half-life business Lung |
| Zdroj: | Radiology. 112(3) |
| ISSN: | 0033-8419 |
| Popis: | Studies of tantalum dust labelled with 182Ta in dogs following either inhalation or insufflation exposures demonstrated that (a) the “alveolarization” of tantalum dust leads to prolonged retention, viz., a mean biological removal half-time greater than two years; (b) mucociliary transport, the dominant clearance mechanism, was somewhat longer than that reported for other "insoluble" dusts and apparently independent of the absolute amount of tantalum present; (c) the minimal surface density suitable for clinical bronchography is of the order of 10 mg tantalum/cm2 of bronchial surface; and (d) radiographic assessments of either airways or alveolar areas cannot utilize a surface deposition of ≤mg/cm2 tantalum and therefore are of limited value in quantitative applications, e.g., absolute tantalum retention. |
| Databáze: | OpenAIRE |
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