Effect of pulsed magnetic stimulation of the facial nerve on cerebral blood flow

Autor: Chisa Yamada, Bruce G. Lyeth, Tamara Heaton, Andrea Garcia, Dawn M. Bielawski, Fernando Castro Prado, Joaquin Azpiroz, Emilio Sacristan, Mark K. Borsody
Rok vydání: 2013
Předmět:
Zdroj: Brain Research. 1528:58-67
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2013.06.022
Popis: In these experiments we define an effective means of pulsed magnetic stimulation of the facial nerve for the purpose of increasing cerebral blood flow (CBF). In normal anesthetized dog and sheep, a focal magnetic field was directed toward the facial nerve within the temporal bone by placing a 6.5 cm figure-8 stimulation coil over the ear. In an initial set of experiments, CBF was measured by laser Doppler flowmetry and the cerebral vasculature was visualized by angiography. The effect of facial nerve stimulation was found to be dependent on stimulation power, frequency, and the precise positioning of the stimulation coil. Furthermore, an increase in CBF was not observed after direct electrical stimulation in the middle ear space, indicating that non-specific stimulation of the tympanic plexus, an intervening neural structure with vasoactive effects, was not responsible for the increase in CBF after pulsed magnetic stimulation. Subsequent experiments using perfusion MRI demonstrated reproducible increases in CBF throughout the forebrain that manifested bilaterally, albeit with an ipsilateral predominance. These experiments support the development of a non-invasive pulsed magnetic facial nerve stimulator that will increase CBF as a treatment of ischemic stroke.
Databáze: OpenAIRE
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