Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis
| Autor: | Anetta Undas, Daniel P. Potaczek, Ewa Wypasek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Aortic valve Genotyping Techniques aortic valve stenosis Gastroenterology calcification lcsh:Chemistry lcsh:QH301-705.5 Spectroscopy Aged 80 and over Calcinosis General Medicine Middle Aged Computer Science Applications C-Reactive Protein medicine.anatomical_structure Echocardiography CRP rs1205 C> Aortic Valve Aortic valve stenosis Cardiology Female Aortic valve calcification CRP Adult Genetic Markers medicine.medical_specialty Biology Polymorphism Single Nucleotide White People Article CRP rs1205 C>T polymorphism Catalysis Inorganic Chemistry Young Adult Internal medicine medicine Humans T polymorphism Physical and Theoretical Chemistry Molecular Biology Aged Organic Chemistry C-reactive protein medicine.disease Minor allele frequency Stenosis lcsh:Biology (General) lcsh:QD1-999 biology.protein Calcification |
| Zdroj: | International Journal of Molecular Sciences, Vol 16, Iss 10, Pp 23745-23759 (2015) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Elevation in C-reactive protein (CRP) levels have been shown in patients with aortic valve stenosis (AS). Minor allele of the CRP gene (CRP) rs1205 C>T polymorphism has been associated with lower plasma CRP concentrations in cohorts of healthy and atherosclerotic patients. Considering the existing similarities between atherosclerosis and AS, we examined the effect of CRP rs1205 C>T polymorphism on the AS severity. Three hundred consecutive Caucasian patients diagnosed with AS were genotyped for the rs1205 C>T polymorphism using the TaqMan assay. Severity of the AS was assessed using transthoracic echocardiography. The degree of calcification was analyzed semi-quantitatively. Carriers of the rs1205 T allele were characterized by elevated serum CRP levels (2.53 (1.51–3.96) vs. 1.68 (0.98–2.90) mg/L, p < 0.001) and a higher proportion of the severe aortic valve calcification (70.4% vs. 55.1%, p = 0.01) compared with major homozygotes. The effect of CRP rs1205 polymorphism on CRP levels is opposite in AS-affected than in unaffected subjects, suggesting existence of a disease-specific molecular regulatory mechanism. Furthermore, rs1205 variant allele predisposes to larger aortic valve calcification, potentially being a novel genetic risk marker of disease progression. |
| Databáze: | OpenAIRE |
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