P-31 changes as a measure of therapy response in resistant and sensitive osteosarcomas implanted into nude mice
| Autor: | J.R. Ballinger, B.P. Croker, K.N. Scott, C.A. Sweeney, H. Kang, J.D. Scott |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
musculoskeletal diseases
Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy Phosphocreatine Ratón medicine.medical_treatment Transplantation Heterologous Biomedical Engineering Biophysics Mice Nude Antineoplastic Agents Sensitivity and Specificity Phosphates Mice Tumor Cells Cultured medicine Surface coil Animals Humans Radiology Nuclear Medicine and imaging Cisplatin Osteosarcoma Chemotherapy Chemistry Significant difference Phosphorus medicine.disease Therapy response Cell culture Neoplasm Transplantation medicine.drug |
| Zdroj: | Magnetic Resonance Imaging. 13:877-883 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/0730-725x(95)00035-f |
| Popis: | Objective: To determine if changes in PCrPi and PME can be used to predict lack of tumor response to chemotherapy in a murine model of a chemotherapy-resistant human osteosarcoma. Material and Methods: Cisplatin-resistant sublines were grown from high-grade cisplatin-sensitive human osteosarcoma. Surface coil localized 31P NMR spectroscopy of implanted cisplatin-resistant and sensitive osteosarcoma tumors in nude mice was performed. Results: A cisplatin-resistant subline of a sensitive human osteosarcoma was developed that was five times more resistant to cisplatin than the parent cell line. Our NMR data shows a statistically significant difference in the change in the PCrPi ratio after treatment between sensitive and resistant osteosarcomas at the α = 0.05 level. Changes in PME were seen in the sensitive tumors but were not statistically significant. Conclusions: Changes in PCrPi predict lack of tumor treatment response in human osteosarcoma implanted into nude mice with a specificity of 70% and a sensitivity of 54%. Monitoring of PCrPi in human osteosarcoma patients may allow detection of response to chemotherapy before conventional imaging techniques. |
| Databáze: | OpenAIRE |
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