Vascular findings in primarily affected and fellow eyes of middle-aged patients with Coats’ disease using multimodal imaging
| Autor: | Sibylle Winterhalter, Julia Löwen, Shideh Schönfeld, Bert Müller, Ira Seibel, Claudia Brockmann, Mirjam Rossel-Zemkouo, Antonia M. Joussen |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
genetic structures Fundus Oculi Vascular Malformations Fundus (eye) Multimodal Imaging 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Optical coherence tomography Ophthalmology medicine Humans Coats' disease Fluorescein Angiography Retrospective Studies 030304 developmental biology Multimodal imaging 0303 health sciences Retina medicine.diagnostic_test business.industry Retinal Vessels Retinal Middle Aged medicine.disease Fluorescein angiography eye diseases Sensory Systems Aged patients Capillaries medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Retinal Telangiectasis sense organs business Tomography Optical Coherence |
| Zdroj: | British Journal of Ophthalmology. 105:1444-1453 |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2020-317101 |
| Popis: | AimsTo investigate the retinal vascular structure and capillary anomalies of affected and fellow eyes of patients with unilateral Coats’ disease using multimodal imaging.MethodsClinical investigation of both eyes of each patient with diagnosed Coats’ disease using ultra-widefield (UWF) fundus imaging, including UWF fluorescein angiography (UWFFA), spectral domain optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A).ResultsWe analysed 38 eyes of 19 patients with unilateral Coats’ disease and found that all fellow eyes (19/19; 100%) revealed vascular alterations, detected by UWFFA, predominantly located in the temporal periphery. Thereby, 89% of the fellow eyes (17/19) presented capillary bed abnormalities, that did not exceed the capillary level; 58% (11/19) presented tortuous abnormalities and 26% (5/19) presented microaneurysmatic abnormalities, exceeding the capillary level. If primarily affected eyes presented central Coats’ specific vascular abnormalities, fellow eyes revealed tortuous vascular abnormalities twice as often (78% (7/9) vs 40% (4/10); P=0.096). In primarily affected eyes, a tendency towards larger foveal avascular zones was revealed, compared to fellow eyes (0.28±0.16 mm2 vs 0.20±0.10 mm2; P=0.123).ConclusionThe use of modern multimodal imaging allows the detection of even subtle vascular changes in fellow eyes of patients with Coats’ disease. Coats’ disease appears to be a bilateral ocular disease with a predominant manifestation in one eye of the affected patients. |
| Databáze: | OpenAIRE |
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