Ablation of endometriotic implants in rabbits by hematoporphyrin derivative photoradiation therapy using the gold vapor laser
| Autor: | Lorraine McKenzie, Muttukrishna Sathananden, Ian J. Forbes, William E. Keye, Michael F. Petrucco, O. M. Petrucco, Prudence A. Cowled, Simon Knowles |
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| Rok vydání: | 1990 |
| Předmět: |
Pathology
medicine.medical_specialty Necrosis medicine.medical_treatment Endometriosis Uterus Photodynamic therapy Dermatology law.invention chemistry.chemical_compound law medicine Animals Hematoporphyrin business.industry Phototherapy Laser Ablation medicine.disease Hematoporphyrins medicine.anatomical_structure chemistry Uterine Neoplasms Female Surgery Gold Laser Therapy Rabbits Implant medicine.symptom business |
| Zdroj: | Lasers in Surgery and Medicine. 10:344-348 |
| ISSN: | 1096-9101 0196-8092 |
| DOI: | 10.1002/lsm.1900100407 |
| Popis: | In a rabbit model, endometriotic lesions were utilized to study hematoporphyrin derivative (HPD) uptake and the effect of photoradiation using the gold vapor laser. Morphological studies confirmed successful induction of ectopic endometrial growth and the lesions displayed preferential HPD uptake compared to normal intraperitoneal structures. Gold vapor laser irradiation of the lesions in HPD pretreated animals produced necrosis of the endometriotic lesions leaving surrounding tissues healthy. Results from this study suggest that HPD-mediated photodynamic therapy may be a suitable means of treating endometriosis in the human. |
| Databáze: | OpenAIRE |
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