Bacterial secretion chaperones
| Autor: | Edith N.G. Houben, Trang H Phan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Protein Folding 030106 microbiology Chaperone Type VII secretion Biology Protein targeting medicine.disease_cause Microbiology Mycobacterium 03 medical and health sciences Bacterial Proteins Genetics medicine Secretion Molecular Biology Bacterial Secretion Systems Substrate recognition Translocon Cell biology Transport protein Protein Transport 030104 developmental biology Proteostasis Secretory protein Chaperone (protein) biology.protein Protein folding Minireview Protein secretion Physiology and Biochemistry Molecular Chaperones |
| Zdroj: | FEMS Microbiology Letters Phan, T H & Houben, E N G 2018, ' Bacterial secretion chaperones : The mycobacterial type VII case ', FEMS Microbiology Letters, vol. 365, no. 18, fny197, pp. 1-8 . https://doi.org/10.1093/femsle/fny197 |
| ISSN: | 0378-1097 |
| DOI: | 10.1093/femsle/fny197 |
| Popis: | Chaperones are central players in maintaining the proteostasis in all living cells. Besides highly conserved generic chaperones that assist protein folding and assembly in the cytosol, additional more specific chaperones have evolved to ensure the successful trafficking of proteins with extra-cytoplasmic locations. Associated with the distinctive secretion systems present in bacteria, different dedicated chaperones have been described that not only keep secretory proteins in a translocation competent state, but often are also involved in substrate targeting to the specific translocation channel. Recently, a new class of such chaperones has been identified that are involved in the specific recognition of substrates transported via the type VII secretion pathway in mycobacteria. In this minireview, we provide an overview of the different bacterial chaperones with a focus on their roles in protein secretion and will discuss in detail the roles of mycobacterial type VII secretion chaperones in substrate recognition and targeting. The role of bacterial chaperones in substrate recognition and targeting in protein secretion with emphasis on type VII secretion |
| Databáze: | OpenAIRE |
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