Thrombin-activatable fibrinolysis inhibitor (TAFI) levels and its polymorphism rs3742264 are associated with dyslipidemia in a cohort of Brazilian subjects
| Autor: | Karina Braga Gomes, Cláudia N. Ferreira, Maria da Gloria Carvalho, Izabela R. Santos, Ana Paula Fernandes, Marinez O. Sousa |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Carboxypeptidase B2 medicine.medical_treatment Clinical Biochemistry Biochemistry Polymorphism Single Nucleotide Cohort Studies Risk Factors Internal medicine Fibrinolysis Genotype Medicine Humans Sedentary lifestyle Dyslipidemias business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease Menopause Endocrinology Cardiovascular Diseases Cohort Female business Body mass index Dyslipidemia Brazil Lipoprotein |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 433 |
| ISSN: | 1873-3492 |
| Popis: | Background Dyslipidemia, a metabolic alteration that affects lipoprotein levels, is considered a major risk factor for atherosclerosis and its complications. Dyslipidemia also affects the hemostatic system, especially impairing fibrinolysis, and increased levels of thrombin-activatable fibrinolysis inhibitor (TAFI) have been associated with cardiovascular events. Objectives and methods This study evaluated the association of acquired risk factors (hypertension, body mass index — BMI, smoking, sedentary lifestyle, use or not of oral contraceptives and hormone replacement therapy, and post-menopause status), the polymorphisms Thr325Ile (rs1926447), Ala147Thr (rs3742264) and + 1542C/G (rs940) in the TAFI gene, and TAFI plasma levels in 109 dyslipidemic and 105 normolipemic individuals. Biochemical analyses and TAFI levels were evaluated by colorimetric/turbidimetric assays and ELISA, respectively. Genotypic and allelic frequencies were determined by polymerase chain reaction (PCR). Results Hypertension, increased BMI, and menopause were more common in dyslipidemic individuals, who had higher TAFI levels. The alleles 325Ile, Ala147, and C showed association with lower TAFI levels. The rs3742264 polymorphism was associated with dyslipidemia in males. Conclusions The results suggest that TAFI levels are independently associated to dyslipidemia and that the polymorphism rs3742264 may be related to cardiovascular risk in male subjects. |
| Databáze: | OpenAIRE |
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