Prognostic value of serum alkaline phosphatase in osteosarcoma
| Autor: | Marco Manfrini, Riccardo Manduchi, Gaetano Bacci, Dante Dallari, Piero Picci, Maurizio Orlandi, Giovanni Pignatti, Avella M |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty genetic structures Adolescent Adjuvant chemotherapy medicine.medical_treatment Normal values Gastroenterology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Humans Neoplasm Metastasis Child Serum alkaline phosphatase Osteosarcoma business.industry Infant Newborn Infant General Medicine Middle Aged medicine.disease Alkaline Phosphatase Prognosis eye diseases Oncology Amputation 030220 oncology & carcinogenesis Child Preschool Clinical value Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0300-8916 |
| Popis: | In 163 patients with osteosarcoma of the extremities treated with adjuvant chemotherapy, serum alkaline phosphatase (SAP) levels were evaluated before treatment and successively closely monitored in an attempt to determine whether serum levels of this enzyme had clinical value in predicting the course of the disease. Of 121 patients with elevated preoperative SAP levels, 78 (64%) recurred. Of 42 patients with normal preoperative SAP levels, only 8 (19%) recurred (P < 0.00001). Of the 140 patients locally treated with amputation, SAP returned to normal values in 77 patients; 46 of these (59%) relapsed. Of the 21 patients whose SAP remained elevated after amputation, all but 2 relapsed (90%). Among 119 patients with normal postoperative values of SAP, at the time of relapse SAP resulted elevated in 22 of 41 patients (53%). These data confirm that in osteosarcoma, preoperative SAP levels have a definite value in establishing the prognosis and that posttreatment follow-up examination should include SAP determination, since persistent elevated or increasing values herald the appearance of a recurrence. |
| Databáze: | OpenAIRE |
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