GLUT-1 Expression: An Aid in Complementing the WHO Oral Epithelial Dysplasia Grading System
| Autor: | Sangram Patro, Priyanka Debta, Gargi S Sarode, Shankargouda Patil, Fakir Mohan Debta, Mahesh Chandra Sahu, Santosh Kumar Swain, Saswati Siddhartha, Sachin C Sarode |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Mild Dysplasia
Epithelial dysplasia Pathology medicine.medical_specialty Hyperkeratosis World Health Organization 03 medical and health sciences 0302 clinical medicine Antigen Humans Medicine Clinical significance General Dentistry Moderate Dysplasia business.industry Mouth Mucosa 030206 dentistry medicine.disease Head and Neck Neoplasms Dysplasia 030220 oncology & carcinogenesis Carcinoma Squamous Cell Immunohistochemistry Mouth Neoplasms business Carcinoma in Situ |
| Zdroj: | The Journal of Contemporary Dental Practice. 21:951-955 |
| ISSN: | 1526-3711 |
| DOI: | 10.5005/jp-journals-10024-2870 |
| Popis: | Aim and objectives The clinicopathologic parameters alone are not sufficient to precisely predict if oral potentially malignant disorders (OPMDs) remain unchanged, i.e., without any malignant changes, regress, or advance to oral squamous cell carcinomas (OSCC). Few of the OPMDs, with or without epithelial dysplasia, may transform to frank OSCC. Discovering various molecular markers that can predict OSCC transformation is essential to develop effective therapeutic strategies. GLUT-1 is one of the hypoxia as well as metabolic indicator markers that have been used to study the metabolic activity of the cells. Hence, given by the World Health Organization (WHO), GLUT-1 expression was studied in various grades of dysplasia to see whether it complements the WHO grading system (mild, moderate, and severe). Materials and methods The study was carried out on paraffin-embedded tissues of 10 normal oral mucosa and 30 OPMD cases. OPMD cases were classified into hyperkeratosis, mild dysplasia, moderate dysplasia, and severe dysplasia groups. Immunohistochemistry was carried out to evaluate the expression of GLUT-1 antigen. Results According to the WHO grading system of dysplasia, 11 (36.66%) cases were classified as hyperkeratosis, 9 (30%) cases were classified as mild dysplasia, 6 (20%) cases as moderate dysplasia, and 4 (13.33%) cases as severe dysplasia. There was a significant increase in GLUT-1 expression from normal to mild, moderate, and severe dysplasia (p value = 0.00). Conclusion The expression of GLUT-1 marker complements the WHO grading system of oral epithelial dysplasia. Clinical significance GLUT-1 expression can be used to complement the WHO grading system to grade epithelial dysplasia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|