Concentrations systémiques d’antibiotiques potentiellement toxiques après administration par pansement imprégné chez un patient brûlé : à propos d’un cas clinique
| Autor: | Romain Guilhaumou, Sandrine Wiramus, Julien Dupouey, Jacques Albanèse, Olivier Blin |
|---|---|
| Přispěvatelé: | Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2016 |
| Předmět: |
medicine.diagnostic_test
business.industry medicine.drug_class Pseudomonas aeruginosa [SCCO.NEUR]Cognitive science/Neuroscience Antibiotics 030208 emergency & critical care medicine equipment and supplies medicine.disease_cause 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Amikacin Therapeutic drug monitoring Anesthesia Toxicity medicine Colistin Pharmacology (medical) business ComputingMilieux_MISCELLANEOUS medicine.drug |
| Zdroj: | Thérapie Thérapie, EDP Sciences-Depuis 2016, la revue Thérapie n’est plus publiée par EDP Sciences.> Therapies (Elsevier), 2016, 71 (5), pp.483-486. ⟨10.1016/j.therap.2016.03.001⟩ |
| ISSN: | 0040-5957 1958-5578 |
| DOI: | 10.1016/j.therap.2016.03.001 |
| Popis: | Severe burned patients present high risk of skins infections, frequently due to Pseudomonas aeruginosa. Impregnated dressings with amikacin or colistin could be a good alternative to obtain effective concentration directly at the infected site. Therapeutic drug monitoring for these antibiotics is currently recommended after an intravenous administration to obtain effective and non-toxic plasmatic concentrations. However, data are lacking about systemic exposition and risk of toxicity after an administration with impregnated dressings. We report the case of a severe burned patient with cutaneous infection treated with amikacin and colistin impregnated dressings, for which plasmatic pharmacokinetic profiles were performed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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