Sex- and age-related differences of metabolic parameters in impaired glucose metabolism and type 2 diabetes compared to normal glucose tolerance
| Autor: | Jana Vrbikova, Giovanni Pacini, Běla Bendlová, Andrea Tura, Alexandra Kautzky-Willer, Ermanno Moro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Carbohydrate metabolism 03 medical and health sciences Sex Factors 0302 clinical medicine Endocrinology Insulin resistance Diabetes mellitus Internal medicine Age related Glucose Intolerance Internal Medicine Humans Insulin Medicine Prediabetes Normal glucose tolerance business.industry Age Factors nutritional and metabolic diseases General Medicine Glucose Tolerance Test Middle Aged medicine.disease Glucose Diabetes Mellitus Type 2 Female Insulin Resistance business |
| Zdroj: | Diabetes Research and Clinical Practice. 146:67-75 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2018.09.019 |
| Popis: | Aims This study analysed potential sex differences in glucose metabolism of European subjects with different degrees of glucose tolerance impairment. Methods Subjects with impaired glucose metabolism, IGM (n = 735), or type 2 diabetes, T2DM (n = 415), were compared to subjects with normal glucose tolerance, NGT (n = 422), with similar BMI. For both males (M) and females (F), 50 years threshold was used for estimation of menopausal/andropausal state. Subjects underwent 75-g OGTT for measurements of insulin sensitivity (OGIS), beta-cell function (insulinogenic index, IGIC), and overall metabolic condition, disposition index (DI). Results In IGM, OGIS did not change with age in both sexes, whereas marked reduction of IGIC was seen in F (p = 0.0003). In T2DM, again OGIS did not change with age, but M ≥ 50 yrs had reduced IGIC and DI (p Conclusions IGM did not reveal relevant changes of insulin resistance with age, but early phase insulin release deteriorated, with higher change in women. T2DM men featured age-related deterioration of glucose metabolism. In women, sex advantage seen in NGT vanished in T2DM, since glucose metabolism was overall not different than in men, both young and elderly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect