Retinal arterial remodeling in patients with pheochromocytoma or paraganglioma and its reversibility following surgical treatment
| Autor: | Mariola Pęczkowska, Anna Klisiewicz, Sadegh Toutounchi, Piotr Hoffman, Andrzej Januszewicz, Aleksander Prejbisz, Barbara Górnicka, Piotr Dobrowolski, M. Gosk-Przybylek, Jerzy Szaflik, Zbigniew Gałązka, Roland E. Schmieder, E. Binczyk, Jacek P. Szaflik, Jacques W.M. Lenders, Ewa Warchoł-Celińska, K. Szymanek, Graeme Eisenhofer, Adrian Doroszko, Magdalena Januszewicz, Joanna Harazny, Marek Kabat |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology Retinal Artery Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Diastole Adrenal Gland Neoplasms Blood Pressure Pheochromocytoma 030204 cardiovascular system & hematology Vascular Remodeling Paraganglioma 03 medical and health sciences chemistry.chemical_compound All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Catecholamines Internal medicine Internal Medicine medicine Humans In patient 030212 general & internal medicine business.industry Retinal Metanephrines medicine.disease medicine.anatomical_structure chemistry Ventricle Hypertension Catecholamine Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Hypertension, 38, 1551-1558 Journal of Hypertension, 38, 8, pp. 1551-1558 |
| ISSN: | 1473-5598 0263-6352 |
| Popis: | OBJECTIVE Structural abnormalities in resistance arteries are a hallmark of patients with hypertension. In hypertensive patients with pheochromocytoma or paraganglioma (PPGL), it is still a matter of debate whether structural vascular changes are because of elevated blood pressure (BP) or to toxic effects of elevated circulating catecholamines. Hence, the aim of our study was to assess whether catecholamine excess and/or elevated BP affect the structure of small retinal arteries in patients with catecholamine-producing tumors. METHODS The study included 27 patients with PPGL and 27 hypertensive patients. All patients underwent biochemical tests for catecholamine excess, echocardiography and analyses of scanning-laser-Doppler-flowmetry (SLDF) both at baseline and 12 months following surgical resection of PPGL. RESULTS Baseline retinal arterial diameter, arterial wall thickness and wall cross sectional area (WCSA) were higher in patients with PPGL as compared with subjects without PPGL (arterial diameter: 110 ± 16.5 vs. 99.5 ± 10.8 μm, wall thickness: 16.3 ± 6.0 vs. 13.5 ± 4.0 μm, WCSA: 4953.9 ± 2472.8 vs. 3784.1 ± 1446.3 μm, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|