Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
| Autor: | Sofia Municoy, Pablo Edmundo Antezana, Martín F. Desimone, Claudio Javier Pérez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
collagen silver nanoparticles Biocompatibility Cannabis sativa wound healing RM1-950 Pharmacology Biochemistry Microbiology Article Silver nanoparticle medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Nanocomposite Chemistry Biomaterial Antimicrobial Infectious Diseases Self-healing hydrogels Collagenase antimicrobial Therapeutics. Pharmacology Wound healing medicine.drug biomaterials |
| Zdroj: | Antibiotics Volume 10 Issue 11 Antibiotics, Vol 10, Iss 1420, p 1420 (2021) |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics10111420 |
| Popis: | Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing. |
| Databáze: | OpenAIRE |
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