Nitrogen-Containing Diterpenoids, Sesquiterpenoids, and Nor-Diterpenoids from Cespitularia taeniata
| Autor: | Ya-Ching Shen, Yu-Chi Lin, Yao-Haur Kuo, Chia-Ching Liaw, Shih-Sheng Wang, Yuan-Bin Cheng, Jiun-Yang Chang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
food.ingredient
Molecular Structure Stereochemistry Cespitularia taeniata Absolute configuration Pharmaceutical Science Biology Ring (chemistry) Anthozoa Article food lcsh:Biology (General) Drug Discovery Organic chemistry Animals cytotoxicity verticillene diterpenoids Diterpenes lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Sesquiterpenes Bond cleavage Human cancer Cespitularia |
| Zdroj: | Marine Drugs Marine Drugs, Vol 13, Iss 9, Pp 5796-5814 (2015) Volume 13 Issue 9 Pages 5796-5814 |
| ISSN: | 1660-3397 |
| Popis: | Two new nitrogen-containing verticillene diterpenoids, cespilamides A and B (1 and 2), three new nitrogen-containing sesquiterpenoids, cespilamides C–E (3–5), and five new norverticillene and verticillene diterpenoids, cespitaenins A–E (6–10), were isolated from the Taiwanese soft coral Cespitularia taeniata. Compound 1 possesses an unusual oxazo ring system at C-10 while compound 2 displays an unprecedented C–C bond cleavage between C-10 and C-11 with an N-ethylphenyl group at C-10. Biogenetic pathways of 1 and 2 are proposed. The absolute configuration of 1 was confirmed by Mosher’s method and molecular mechanics calculations (MM2). The cytotoxicities of compounds 1–10 were evaluated against a small panel of human cancer cell lines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|